Pediatric Mandibular Central Giant Cell Granuloma: Neoadjuvant Immunotherapy to Minimize Surgical Resection
| Autor: | S. Ryan Hall, Christine Oh, Jason Lin, Salvatore C. Lettieri, Jeffrey C. Mecham |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Surgical resection
medicine.medical_specialty medicine.medical_treatment Mandible Lesion 03 medical and health sciences 0302 clinical medicine Granuloma Giant Cell medicine Humans Mandibular Diseases Mandibular reconstruction Child 030223 otorhinolaryngology business.industry 030206 dentistry General Medicine Immunotherapy Plastic Surgery Procedures medicine.disease Neoadjuvant Therapy Surgery Denosumab Otorhinolaryngology Extensive resection medicine.symptom business Central giant-cell granuloma medicine.drug |
| Zdroj: | Journal of Craniofacial Surgery. 32:e267-e269 |
| ISSN: | 1536-3732 1049-2275 |
| DOI: | 10.1097/scs.0000000000007112 |
| Popis: | Central giant cell granuloma (CGCG) is a relatively uncommon benign bony lesion accounting for approximately 7% of all non-neoplastic lesions of the jaw. The clinical behavior of CGCG can vary from a slow-growing, painless lesion to fast-growing and locally destructive. When such a lesion involves the mandible, this can be quite debilitating for the patient, inhibiting oral intake and requiring an extensive resection and bone graft reconstruction. The authors present a case of effectively decreasing the surgical morbidity associated with a large and rapidly growing CGCG of the mandible in a pediatric patient. Neoadjuvant immunotherapy with denosumab (human monoclonal antibody) facilitated treatment of the tumor without the need for a large resection which would have otherwise necessitated a vascularized bony mandibular reconstruction. Consideration of neoadjuvant medical management of CGCG as the primary treatment is advocated. |
| Databáze: | OpenAIRE |
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