Three‐dimensional mapping of the attenuation coefficient in optical coherence tomography to enhance breast tissue microarchitecture contrast
| Autor: | Sally McLaren, Rowan W. Sanderson, Brendan F. Kennedy, Lixin Chin, Ken Y. Foo, Bruce Latham, Qi Fang, Christobel Saunders, Benjamin F. Dessauvagie, Renate R. Zilkens, Devina D. Lakhiani |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
media_common.quotation_subject General Physics and Astronomy Breast Neoplasms Mastectomy Segmental 01 natural sciences General Biochemistry Genetics and Molecular Biology 010309 optics Elasticity Imaging Techniques Optical coherence tomography 0103 physical sciences medicine Humans Contrast (vision) General Materials Science Breast Mastectomy media_common Multimodal imaging Breast tissue medicine.diagnostic_test Attenuation 010401 analytical chemistry General Engineering General Chemistry Segmental Mastectomy 0104 chemical sciences Attenuation coefficient Female Tomography Optical Coherence Biomedical engineering |
| Zdroj: | Journal of Biophotonics. 13 |
| ISSN: | 1864-0648 1864-063X |
| DOI: | 10.1002/jbio.201960201 |
| Popis: | Effective intraoperative tumor margin assessment is needed to reduce re-excision rates in breast-conserving surgery (BCS). Mapping the attenuation coefficient in optical coherence tomography (OCT) throughout a sample to create an image (attenuation imaging) is one promising approach. For the first time, three-dimensional OCT attenuation imaging of human breast tissue microarchitecture using a wide-field (up to ~45 × 45 × 3.5 mm) imaging system is demonstrated. Representative results from three mastectomy and one BCS specimen (from 31 specimens) are presented with co-registered postoperative histology. Attenuation imaging is shown to provide substantially improved contrast over OCT, delineating nuanced features within tumors (including necrosis and variations in tumor cell density and growth patterns) and benign features (such as sclerosing adenosis). Additionally, quantitative micro-elastography (QME) images presented alongside OCT and attenuation images show that these techniques provide complementary contrast, suggesting that multimodal imaging could increase tissue identification accuracy and potentially improve tumor margin assessment. |
| Databáze: | OpenAIRE |
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