Efficacy of Lactobacillus-supplemented triple therapy for Helicobacter pylori infection in children: a meta-analysis of randomized controlled trials
| Autor: | Guo-Qiang Zhang, Zhong-Yue Li, Hao-Ran Fang, Jing-Yi Cheng |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Adolescent macromolecular substances Gastroenterology law.invention Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law 030225 pediatrics Internal medicine Lactobacillus Medicine Humans 030212 general & internal medicine Child Randomized Controlled Trials as Topic biology Helicobacter pylori business.industry Incidence (epidemiology) Probiotics biology.organism_classification Confidence interval Anti-Bacterial Agents Diarrhea Treatment Outcome Relative risk Meta-analysis Child Preschool Pediatrics Perinatology and Child Health Dietary Supplements Drug Therapy Combination medicine.symptom business |
| Zdroj: | European journal of pediatrics. 178(1) |
| ISSN: | 1432-1076 |
| Popis: | Therapy-related side effects and severe antimicrobial resistance still remain an obstacle to Helicobacter pylori eradication. This meta-analysis aimed to investigate the efficacy of Lactobacillus-supplemented triple therapy on H. pylori eradication rates and therapy-related side effects in children. Five studies involving 484 pediatric patients were included in our analysis. The pooled relative risk (RR) for eradication rates in the Lactobacillus group versus the control group was 1.19 [95% confidence interval (CI) 1.07-1.33]. In subgroup analyses based on dose and duration of Lactobacillus supplementation, the pooled RRs for eradication rates were 1.36 (95% CI 1.15-1.60) in the high-dose group, 1.08 (95% CI 0.86-1.35) in the low-dose group, 1.24 (95% CI 1.06-1.46) in the long-term group, and 1.17 (95% CI 0.96-1.44) in the short-term group. With respect to side effects, Lactobacillus supplementation significantly reduced the incidence of diarrhea (RR = 0.30, 95% CI 0.10-0.85).Conclusions: Lactobacillus, as an adjunct to triple therapy, can increase H. pylori eradication rates as well as reduce the incidence of therapy-related diarrhea in children. And a higher dose and a longer duration of supplementation may conduce to the positive impact of Lactobacillus on H. pylori eradication. What is Known: • Probiotics-supplemented triple therapy may be beneficial in improving H. pylori eradication rates and reducing therapy-related side effects in children. However, not all probiotics are beneficial to H. pylori eradication and the pooled outcomes based on different probiotics may be erroneously extrapolated to other ineffective strains. What is New: • Lactobacillus, as an adjunct to triple therapy, can increase H. pylori eradication rates as well as reduce the incidence of therapy-related diarrhea in children. |
| Databáze: | OpenAIRE |
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