Dietary fructose inhibits intestinal calcium absorption and induces vitamin D insufficiency in CKD
| Autor: | Sue A. Shapses, Ronaldo P. Ferraris, Yves Sabbagh, Donatella M. Casirola, Veronique Douard, Shozo H. Sugiura, Abbas Asgerally |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Calcitriol Diet therapy chemistry.chemical_element Fructose Calcium Kidney Nephrectomy Intestinal absorption vitamin D deficiency Phosphates Rats Sprague-Dawley Hyperphosphatemia chemistry.chemical_compound Bone Density Internal medicine medicine Dietary Carbohydrates Animals Calcifediol Calcium metabolism 25-Hydroxyvitamin D3 1-alpha-Hydroxylase business.industry General Medicine medicine.disease Vitamin D Deficiency Rats Disease Models Animal Endocrinology Glucose Basic Research chemistry Intestinal Absorption Nephrology Chronic Disease Kidney Diseases business medicine.drug |
| Zdroj: | Journal of the American Society of Nephrology : JASN. 21(2) |
| ISSN: | 1533-3450 |
| Popis: | Renal disease leads to perturbations in calcium and phosphate homeostasis and vitamin D metabolism. Dietary fructose aggravates chronic kidney disease (CKD), but whether it also worsens CKD-induced derangements in calcium and phosphate homeostasis is unknown. Here, we fed rats diets containing 60% glucose or fructose for 1 mo beginning 6 wk after 5/6 nephrectomy or sham operation. Nephrectomized rats had markedly greater kidney weight, blood urea nitrogen, and serum levels of creatinine, phosphate, and calcium-phosphate product; dietary fructose significantly exacerbated all of these outcomes. Expression and activity of intestinal phosphate transporter, which did not change after nephrectomy or dietary fructose, did not correlate with hyperphosphatemia in 5/6-nephrectomized rats. Intestinal transport of calcium, however, decreased with dietary fructose, probably because of fructose-mediated downregulation of calbindin 9k. Serum calcium levels, however, were unaffected by nephrectomy and diet. Finally, only 5/6-nephrectomized rats that received dietary fructose demonstrated marked reductions in 25-hydroxyvitamin D(3) and 1,25-dihydroxyvitamin D(3) levels, despite upregulation of 1alpha-hydroxylase. In summary, excess dietary fructose inhibits intestinal calcium absorption, induces marked vitamin D insufficiency in CKD, and exacerbates other classical symptoms of the disease. Future studies should evaluate the relevance of monitoring fructose consumption in patients with CKD. |
| Databáze: | OpenAIRE |
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