Facilitatory rTMS over the Supplementary Motor Cortex Impedes Gait Performance in Parkinson Patients with Freezing of Gait

Autor:	Regina Wegener, Georg Kägi, Marie T. Krüger, Julia Walch, Florent Baty, Stephan Bohlhalter, Stefan Hägele-Link, Florian Brugger
Rok vydání:	2021
Předmět:	medicine.medical_specialty Parkinson's disease genetic structures business.industry General Neuroscience supplementary motor cortex STRIDE Motor control Stimulation Stride length medicine.disease Article lcsh:RC321-571 freezing of gait Preferred walking speed Physical medicine and rehabilitation Gait (human) medicine.anatomical_structure rTMS medicine Parkinson’s disease business lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry human activities Motor cortex
Zdroj:	Brain Sciences Brain Sciences, Vol 11, Iss 321, p 321 (2021) Volume 11 Issue 3
ISSN:	2076-3425
Popis:	Freezing of gait (FOG) in Parkinson’s disease (PD) occurs frequently in situations with high environmental complexity. The supplementary motor cortex (SMC) is regarded as a major network node that exerts cortical input for motor control in these situations. We aimed at assessing the impact of single-session (excitatory) intermittent theta burst stimulation (iTBS) of the SMC on established walking during FOG provoking situations such as passing through narrow spaces and turning for directional changes. Twelve PD patients with FOG underwent two visits in the off-medication state with either iTBS or sham stimulation. At each visit, spatiotemporal gait parameters were measured during walking without obstacles and in FOG-provoking situations before and after stimulation. When patients passed through narrow spaces, decreased stride time along with increased stride length and walking speed (i.e., improved gait) was observed after both sham stimulation and iTBS. These effects, particularly on stride time, were attenuated by real iTBS. During turning, iTBS resulted in decreased stride time along with unchanged stride length, a constellation compatible with increased stepping frequency. The observed iTBS effects are regarded as relative gait deterioration. We conclude that iTBS over the SMC increases stepping frequency in PD patients with FOG, particularly in FOG provoking situations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2229946b8a97673befca4b9022acec9 https://pubmed.ncbi.nlm.nih.gov/33802532 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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