Three Novel Sterols Isolated from Selaginella tamariscina with Antiproliferative Activity in Leukemia Cells
| Autor: | Zhan-Lin Li, Yongkui Jing, Liang-liang Gao, Yi Sha, Hui-Ming Hua, Yue-Hu Pei, Shi-Liang Yin, Guang Shi |
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| Rok vydání: | 2007 |
| Předmět: |
Selaginellaceae
Human leukemia Stereochemistry Pharmaceutical Science Selaginella tamariscina HL-60 Cells Growth inhibitory Biology Analytical Chemistry Drug Discovery medicine Humans Differentiation induction Cell Proliferation Pharmacology Plant Extracts Cell growth Organic Chemistry medicine.disease Antineoplastic Agents Phytogenic Leukemia Complementary and alternative medicine Biochemistry Molecular Medicine Phytotherapy |
| Zdroj: | Planta Medica. 73:1112-1115 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2007-981562 |
| Popis: | Three new sterols, 3beta,16alpha-dihydroxy-5alpha,17beta-cholestan-21-carboxylic acid (1), 3beta-acetoxy-16alpha-hydroxy-5alpha,17beta-cholestan-21-carboxylic acid (2) and 3beta-(3-hydroxybutyroxy)-16alpha-hydroxy-5alpha,17beta-cholestan-21-carboxylic acid (3) were isolated from Selaginella tamariscina (Beauv.) Spring (Selaginellaceae). Their structures were elucidated based on NMR analyses. The growth inhibitory effects and differentiation induction abilities of compounds 1 - 3 were determined in human leukemia HL-60 cells. Compound 1 was more effective than compounds 2 and 3 in inhibiting cell growth, but compound 3 was more effective than compounds 1 and 2 in enhancing induction of all- trans-retinoic acid differentiation. |
| Databáze: | OpenAIRE |
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