Experience in qualitative and quantitative FDG PET in follow-up of patients with suspected recurrence from head and neck cancer
| Autor: | J.M. Nuutinen, Timo Kurki, Paula Lindholm, S. Holm, Maria Lapela, I. Bjornskov, Poul Bretlau, H. Sand Hansen, A. Eigtved, Lars Friberg, Sirkku Jyrkkiö, Olof Solin, Heikki Minn, E. Sutinen, Mikael Jensen, Reidar Grénman |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Visual interpretation Denmark Malignancy Body weight Sensitivity and Specificity Diagnosis Differential Fluorodeoxyglucose F18 medicine Humans Head and neck Grading (tumors) Finland Aged medicine.diagnostic_test business.industry Head and neck cancer Middle Aged medicine.disease Prognosis Oncology Positron emission tomography Head and Neck Neoplasms Tracer uptake Female Radiology Neoplasm Recurrence Local Radiopharmaceuticals Nuclear medicine business Tomography X-Ray Computed Follow-Up Studies Tomography Emission-Computed |
| Zdroj: | European journal of cancer (Oxford, England : 1990). 36(7) |
| ISSN: | 0959-8049 |
| Popis: | We evaluated positron emission tomography (PET) with 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) in the detection of recurrent head and neck cancer, and compared visual and quantitative interpretation of PET images for their accuracy in the identification of tumour recurrence. Sixty-two FDG PET studies were performed in 56 patients having a total of 81 lesions, which were clinically suspected for recurrent carcinoma of the head and neck. The PET images were interpreted visually, and tracer uptake was quantitated as the standardised uptake value adjusted to body weight (SUV). Sensitivity of visual interpretation of the PET images for the presence of malignancy ranged from 84 to 95%, and specificity from 84 to 93%, respectively, depending on the selected scheme for grading of the lesions. Malignant lesions accumulated significantly more FDG than the benign ones (the median SUVs were 6.8 and 3.3, respectively, P0.001). However, there was a wide overlap of the FDG uptake values between these two groups. Hence, the highest accuracy of quantitative analysis in correct identification of tumour recurrence (75% at Receiver Operating Curve analysis) was inferior to that of visual analysis (89%). FDG PET is feasible for the detection of recurrent head and neck cancer. Although quantitation of FDG uptake using SUV shows significantly higher tracer concentrations for malignant than benign lesions, the wide overlap of individual SUVs between these two groups is a serious concern in diagnostic evaluation. Therefore, in clinical practice it may be preferable to identify the presence of tumour recurrence within this patient group by qualitative interpretation of the PET images. |
| Databáze: | OpenAIRE |
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