Assessment of Bone Turnover Biomarkers in Lead-Battery Workers with Long-Term Exposure to Lead

Autor: Bhavani Shankara Bagepally, Ravibabu Kalahasthi, Tapu Barman
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Deoxypyridinoline
010501 environmental sciences
01 natural sciences
Bone remodeling
chemistry.chemical_compound
pyridinoline
Manufacturing and Industrial Facilities
hydroxyproline
Workplace
Tartrate-resistant acid phosphatase
0303 health sciences
Pyridinoline
biology
Middle Aged
Resorption
Isoenzymes
Osteocalcin
lcsh:Industrial medicine. Industrial hygiene
Alkaline phosphatase
Original Article
Bone Remodeling
deoxypyridinoline
alkaline phosphatase
bone resorption
Adult
medicine.medical_specialty
Acid Phosphatase
osteocalcin
Bone resorption
03 medical and health sciences
lcsh:RC963-969
Electric Power Supplies
Internal medicine
Occupational Exposure
medicine
Humans
030304 developmental biology
0105 earth and related environmental sciences
lead
business.industry
Public Health
Environmental and Occupational Health
Lead Poisoning
Endocrinology
Cross-Sectional Studies
chemistry
Case-Control Studies
biology.protein
tartrate-resistant acid phosphatase
business
Biomarkers
Zdroj: The International Journal of Occupational and Environmental Medicine, Vol 11, Iss 3 July, Pp 140-7 (2020)
BASE-Bielefeld Academic Search Engine
The International Journal of Occupational and Environmental Medicine
ISSN: 2008-6814
2008-6520
Popis: Background: The major portion of lead in the body resides in skeletal system. The bone turnover affects the release of lead into the circulation from bones. The bone turnover biomarkers (BTM) in lead-battery workers with long-term exposure to lead have not been explored yet. Objective: To evaluate the BTM (formation and resorption) in lead-battery workers with long-term exposure to lead in lead-battery manufacturing plant. Methods: 176 male lead-exposed workers and 80 matched comparison group were studied. All participants were examined for blood lead levels (BLLs), bone formation biomarkers—serum osteocalcin (OC), alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BALP)—and bone resorption biomarkers—serum pyridinoline (PYD), deoxypyridinoline (DPYD), tartarate-resistant acid phosphatase-5b (TRACP-5b), and urinary hydroxyproline (UHYP). Results: We found a significantly higher bone formation biomarkers such as BALP (p=0.007) and bone resorption biomarkers, eg, PYD (p=0.048), TRCAP-5b (p=0.001), and UHYP (p=0.001) in lead-exposed workers. A significant (p=0.041) negative correlation (ρ -0.128) was noted between BLLs and OC. A significant positive correlation was noted between BLLs and TRACP-5b (ρ 0.176, p=0.005) and UHYP (ρ 0.258, p=0.004). Serum OC (p=0.040) and UHYP (p=0.015) levels changed significantly with BLL level. Bone resorption biomarkers levels—PYD, TRACP-5b, and BALP—were higher among those with higher BLLs levels. The duration of exposure was significantly associated with BALP (p=0.037), DPYD (p=0.016), TRACP5b (p=0.001), and UHYP (p=0.002) levels. Conclusion: Long-term lead exposure affects the bone turnover.
Databáze: OpenAIRE
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