Reversal learning strategy in adolescence is associated with prefrontal cortex activation
| Autor: | Lydia Romund, Lorenz Deserno, Rebecca Boehme, Diana Raufelder, Patricia Pelz, Anne Beck, Sabrina Golde, Andrew Wold, Robert C. Lorenz, Eva Flemming, Andreas Heinz, Joachim Behr, Tobias Gleich |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Aging Adolescent Prefrontal Cortex CBCL Reversal Learning Stimulus (physiology) Gyrus Cinguli 050105 experimental psychology Developmental psychology 03 medical and health sciences Executive Function 0302 clinical medicine Reward medicine Reinforcement learning Humans 0501 psychology and cognitive sciences Prefrontal cortex Child Behavior Checklist Brain Mapping medicine.diagnostic_test General Neuroscience 05 social sciences Cognition Magnetic Resonance Imaging Female Psychology Functional magnetic resonance imaging Insula Reinforcement Psychology 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Neuroscience |
| Popis: | Adolescence is a critical maturation period for human cognitive control and executive function. In this study, a large sample of adolescents (n = 85) performed a reversal learning task during functional magnetic resonance imaging. We analyzed behavioral data using a reinforcement learning model to provide individually fitted parameters and imaging data with regard to reward prediction errors (PE). Following a model-based approach, we formed two groups depending on whether individuals tended to update expectations predominantly for the chosen stimulus or also for the unchosen one. These groups significantly differed in their problem behavior score obtained using the child behavior checklist (CBCL) and in a measure of their developmental stage. Imaging results showed that dorsolateral striatal areas covaried with PE. Participants who relied less on learning based on task structure showed less prefrontal activation compared with participants who relied more on task structure. An exploratory analysis revealed that PE-related activity was associated with pubertal development in prefrontal areas, insula and anterior cingulate. These findings support the hypothesis that the prefrontal cortex is implicated in mediating flexible goal-directed behavioral control. |
| Databáze: | OpenAIRE |
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