The usefulness of measuring the anion gap in diagnosing metformin-associated lactic acidosis: a case series
| Autor: | María Antonia Mangues-Bafalluy, Jesus Ruiz-Ramos, Ana Juanes-Borrego, Laura Lozano-Polo, Iván Agra-Montava, Mireia Puig-Campmany |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Anions
Male medicine.medical_specialty lcsh:Medicine Anion gap Renal function Case Report 030226 pharmacology & pharmacy Gastroenterology 03 medical and health sciences Acute renal failure 0302 clinical medicine Diabetes mellitus Internal medicine Cations medicine Humans Hypoglycemic Agents Lactic Acid Adverse effect Acidosis Aged Acid-Base Equilibrium Aged 80 and over business.industry lcsh:R Diabetes 030208 emergency & critical care medicine Metabolic acidosis General Medicine Middle Aged medicine.disease Metformin Diabetes Mellitus Type 2 Lactic acidosis Acidosis Lactic Female Emergency care medicine.symptom business medicine.drug |
| Zdroj: | Journal of Medical Case Reports Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-4 (2021) |
| ISSN: | 1752-1947 |
| Popis: | Background Metformin-associated lactic acidosis (MALA) is a widely documented adverse event of metformin. Despite being considered one of the main causes of metabolic acidosis, the association between an anion gap and MALA diagnosis is still uncertain. Case presentation Cases involving six Caucasian patients with suspected MALA who were admitted to the emergency department were analysed. All these patients presented with pH values < 7.35, lactate levels > 2 mmol/L, and estimated glomerular filtration < 30 mL/min. Metformin plasma concentrations were > 2.5 mg/L in all the patients. The highest metformin concentrations were not found in the patients with the highest lactate levels. The anion gap values ranged from 12.3 to 39.3, with only two patients exhibiting values > 14. Conclusions In patients with MALA, there is a significant variability in the anion gap values, which is not related to the level of metformin accumulation, and therefore, it is doubtful whether measuring anion gaps is useful as an approach for MALA diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink