Insights into Binding of Single-Stranded Viral RNA Template to the Replication–Transcription Complex of SARS-CoV-2 for the Priming Reaction from Molecular Dynamics Simulations

Autor:	Jimin Wang, Yuanjun Shi, Krystle Reiss, Brandon Allen, Federica Maschietto, Elias Lolis, William H. Konigsberg, George P. Lisi, Victor S. Batista
Rok vydání:	2022
Předmět:	SARS-CoV-2 COVID-19 Humans RNA Viral Molecular Dynamics Simulation Viral Nonstructural Proteins Biochemistry
Zdroj:	Biochemistry. 61:424-432
ISSN:	1520-4995 0006-2960
Popis:	A minimal replication-transcription complex (RTC) of SARS-CoV-2 for synthesis of viral RNAs includes the nsp12 RNA-dependent RNA polymerase and two nsp8 RNA primase subunits for
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2189129e0b2373f6747c690fbad2040 https://doi.org/10.1021/acs.biochem.1c00755 Zobrazit plný text záznamu