Human papillomavirus type 5 E6 oncoprotein represses the transforming growth factor beta signaling pathway by binding to SMAD3
| Autor: | Patricia Cassonnet, Yves Jacob, Michel Favre, Jose-Andres Mendoza |
|---|---|
| Přispěvatelé: | Génétique, Papillomavirus et Cancer Humain, Institut Pasteur [Paris], Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
MESH: Signal Transduction
Oncogene Proteins Immunology Down-Regulation Biology Alphapapillomavirus medicine.disease_cause MESH: Two-Hybrid System Techniques Microbiology MESH: Down-Regulation 03 medical and health sciences Transactivation 0302 clinical medicine Downregulation and upregulation Transforming Growth Factor beta Virology Two-Hybrid System Techniques medicine Humans MESH: Smad3 Protein Smad3 Protein MESH: Alphapapillomavirus MESH: Transforming Growth Factor beta 030304 developmental biology Genetics 0303 health sciences MESH: Humans integumentary system Epidermodysplasia verruciformis Oncogene Proteins Viral medicine.disease Yeast 3. Good health Cell biology Virus-Cell Interactions 030220 oncology & carcinogenesis Insect Science MESH: Oncogene Proteins Viral [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Signal transduction Carcinogenesis Transforming growth factor Signal Transduction |
| Zdroj: | Journal of Virology Journal of Virology, American Society for Microbiology, 2006, 80 (24), pp.12420-4. ⟨10.1128/JVI.02576-05⟩ Journal of Virology, 2006, 80 (24), pp.12420-4. ⟨10.1128/JVI.02576-05⟩ |
| ISSN: | 0022-538X 1098-5514 |
| DOI: | 10.1128/JVI.02576-05⟩ |
| Popis: | Mechanisms of cellular transformation associated with human papillomavirus type 5 (HPV5), which is responsible for skin carcinomas in epidermodysplasia verruciformis (EV) patients, are poorly understood. Using a yeast two-hybrid screening and molecular and cellular biology experiments, we found that HPV5 oncoprotein E6 interacts with SMAD3, a key component in the transforming growth factor β1 (TGF-β1) signaling pathway. HPV5 E6 inhibits SMAD3 transactivation by destabilizing the SMAD3/SMAD4 complex and inducing the degradation of both proteins. Interestingly, the E6 protein of nononcogenic EV HPV9 failed to interact with SMAD3, suggesting that downregulation of the TGF-β1 signaling pathway could be a determinant in HPV5 skin carcinogenesis. |
| Databáze: | OpenAIRE |
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