Systematic Review and Meta-Analysis of the Efficacy of MLC901 (NeuroAiD IITM) for Acute Ischemic Brain Injury in Animal Models
| Autor: | Asra Al Fauzi, Gadis Meinar Sari, Budi Utomo, I.G.M. Aswin R. Ranuh, Nur Setiawan Suroto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment RX1-681 Neuroaid Homeopathy Ischemic brain injury medicine.disease Food and drug administration Other systems of medicine Complementary and alternative medicine Meta-analysis Emergency medicine Ischemic stroke medicine business Stroke RZ201-999 |
| Zdroj: | Journal of Evidence-Based Integrative Medicine, Vol 26 (2021) |
| ISSN: | 2515-690X |
| DOI: | 10.1177/2515690x211039219 |
| Popis: | Introduction. Moleac (MLC) 901 is a traditional Chinese medication approved by the Sino Food and Drug Administration in 2001 for treating stroke. This study aims to analyze the efficacy of MLC901 in animal stroke models after medial cerebral artery occlusion (MCAO). Methods. Literature selection was performed according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA) 2015. Inclusion criteria for the experimental studies were the use of animal models, publication in English between 1990 and 2020, information regarding the intervention technique used, and outcomes regarding the efficacy of MLC901 administration. Results. MLC901 administration resulted in significantly less infarction volume by a mean difference of 17.17 compared to the control group (p < .00001). The MLC901 group resulted in significant improvement in 5-bromo-20-deoxyuridine (BrdU)-positive cells expression by a mean difference of 662.79 (p < .00001) and neurological function, which was indicated by a mean difference in the Bederson Neurological Outcome Score of 1.40 (p < .00001). Conclusions. MLC901 administration in an animal stroke model resulted in a better reduction in infarction volume and improvement in BrdU expression and neurologic function. These data could help in further determining the efficacy of MLC901 for acute ischemic brain injury in humans. |
| Databáze: | OpenAIRE |
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