C-reactive protein and hypertension among Ghanaian migrants and their homeland counterparts: the Research on Obesity and Diabetes among African Migrants study
| Autor: | Kerstin Klipstein-Grobusch, Erik Beune, Eva L. van der Linden, Silver Bahendeka, Karlijn Meeks, Bert-Jan H. van den Born, Charles Agyemang, Joshua A.N. van Apeldoorn |
|---|---|
| Přispěvatelé: | Graduate School, Public and occupational health, Vascular Medicine, APH - Global Health, APH - Health Behaviors & Chronic Diseases, ACS - Atherosclerosis & ischemic syndromes, APH - Methodology, APH - Personalized Medicine, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Physiology Ghanaians Logistic regression Ghana Migrants C-reactive protein Risk Factors Inflammatory marker Diabetes mellitus parasitic diseases Diabetes Mellitus Prevalence Internal Medicine medicine Humans Obesity cardiovascular diseases Transients and Migrants Inflammation biology business.industry Public health Original Articles Odds ratio medicine.disease Confidence interval Cross-Sectional Studies Hypertension biology.protein Blood pressure Female Cardiology and Cardiovascular Medicine business Demography |
| Zdroj: | Journal of hypertension, 40(2), 283-291. Lippincott Williams and Wilkins Journal of Hypertension |
| ISSN: | 0263-6352 |
| Popis: | Background: Hypertension (HTN) is a growing public health problem in sub-Saharan Africa (SSA) and SSA migrants in Europe. Elevated levels of inflammatory marker C-reactive protein (CRP) have been linked to HTN but the relationship of CRP and HTN among SSA populations has not been studied. To address this knowledge gap, we studied the association between CRP and HTN in migrant and nonmigrant SSA populations residing in different settings. Methods: Cross-sectional data from the multicentre Research on Obesity and Diabetes among African Migrants (RODAM) study were analysed including 5683 Ghanaians aged at least 18 years, residing in rural and urban Ghana, and Europe. Multivariate logistic regression analyses were used to assess the association between high levels of CRP (≥3 mg/l) and HTN (SBP ≥140 mmHg and/or DBP ≥90 mmHg and/or use of antihypertensive medication) per geographical site and sex. Results: The association between CRP levels and HTN varied by sex and geographical location. In age-adjusted models, there was an association between high CRP levels and HTN in urban-Ghanaian women (odds ratio 1.50, 95% confidence interval 1.10–2.03), and European-Ghanaian men (1.68, 1.16–2.43) and women (1.63, 1.28–2.07). However, these associations were attenuated after adjustment for conventional risk factors, especially BMI. No association was found in rural-Ghanaians or urban-Ghanaian men. Conclusion: Our findings show an association between CRP and HTN among Ghanaian migrants and urban-Ghanaian women, however, this was largely explained by conventional risk factors. Thus, prevention of conventional risk factors, in particular obesity, may help to reduce the potentially low-grade inflammatory mechanism underlying HTN. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|