Treatment of metastatic neuroblastoma with systemic oncolytic virotherapy delivered by autologous mesenchymal stem cells: an exploratory study
| Autor: | Javier García-Castro, Manel Cascallo, Jordi Martinez-Quintanilla, Manuel Ramírez, M del Mar Arriero, Ramon Alemany, L Madero, A. Lassaletta |
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| Rok vydání: | 2010 |
| Předmět: |
Oncolytic adenovirus
Male Cancer Research Pathology medicine.medical_specialty Metastatic neuroblastoma Therapeutic approach Neuroblastoma Cell Line Tumor medicine Humans Molecular Biology Oncolytic Virotherapy business.industry Mesenchymal stem cell Cancer Mesenchymal Stem Cells medicine.disease Oncolytic virus Oncolytic Viruses Child Preschool Systemic administration Cancer research Molecular Medicine business |
| Zdroj: | Cancer gene therapy. 17(7) |
| ISSN: | 1476-5500 |
| Popis: | Treatment of metastatic tumors with engineered adenoviruses that replicate selectively in tumor cells is a new therapeutic approach in cancer. Systemic administration of these oncolytic adenoviruses lack metastatic targeting ability. The tumor stroma engrafting property of intravenously injected mesenchymal stem cells (MSCs) may allow the use of MSCs as cellular vehicles for targeted delivery. In this work, we study the safety and the efficacy of infusing autologous MSCs infected with ICOVIR-5, a new oncolytic adenovirus, for treating metastatic neuroblastoma. Four children with metastatic neuroblastoma refractory to front-line therapies received several doses of autologous MSCs carrying ICOVIR-5, under an approved preliminary study. The tolerance to the treatment was excellent. A complete clinical response was documented in one case, and the child is in complete remission 3 years after this therapy. We postulate that MSCs can deliver oncolytic adenoviruses to metastatic tumors with very low systemic toxicity and with beneficial antitumor effects. |
| Databáze: | OpenAIRE |
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