Potentiation of the anticoagulation effect of warfarin by the herbal remedy Shu-Jing-Hwo-Shiee-Tang in rats: The dosing regimen and pharmacokinetic interaction
| Autor: | Chung-Kuang Lu, Chiung-Chiao Huang, Sien-Hung Yang, Hong-Jaan Wang, Yune-Fang Ueng |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pharmaceutical Science Administration Oral Pharmacology 030226 pharmacology & pharmacy Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Hesperidin 0302 clinical medicine Oral administration Medicine Animals Pharmacology (medical) Drug Interactions Blood Coagulation Prothrombin time medicine.diagnostic_test Dose-Response Relationship Drug business.industry Warfarin Hesperetin Area under the curve Anticoagulants Paeoniflorin Rats Coagulation chemistry Prothrombin Time business 030217 neurology & neurosurgery medicine.drug Drugs Chinese Herbal |
| Zdroj: | Drug metabolism and pharmacokinetics. 32(1) |
| ISSN: | 1880-0920 |
| Popis: | The herbal remedy Shu-Jing-Hwo-Shiee-Tang (SJHST) has been used in traditional Chinese medical care for the treatment of osteoarthritis. This study aims to examine the influence of SJHST on the oxidation and anticoagulation effect of warfarin in male rats. In three SJHST preparations (S1–S3), hesperidin, gentiopicrin, and paeoniflorin were identified as chemical marker ingredients. The inhibition of liver microsomal warfarin 7-hydroxylation (WOH) activity by 50% methanolic extracts of SJHST was potentiated by β-glucosidase pretreatment, but not by NADPH-fortified microsomal preincubation. Among various ingredients and their β-glucosidase-hydrolyzed products, hesperetin caused the most potent inhibition of WOH. Oral administration of S2 to rats at 2 h after warfarin treatment (WS2 2-h post ), but not co-treatment (WS2 co ), decreased warfarin clearance and increased the maximal plasma concentration and the area under the curve (AUC 0-t , AUC 0-∞ ) of plasma concentration versus time of warfarin administration. S2 and S3 did not change the coagulation parameters. At 24 h after warfarin administration, the WS2 2-h post and WS3 2-h post groups had a prothrombin time longer than that of the warfarin group. These results demonstrate that a 2-h post-treatment of rats with SJHST caused pharmacokinetic interaction with warfarin, resulting in prothrombin time prolongation. |
| Databáze: | OpenAIRE |
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