Coronary Calcium Scores 6 Years After Bariatric Surgery
| Autor: | Richard E. Gress, Travis Ault, Steven C. Hunt, Tiffany Priester, Lance E. Davidson, Sheldon E. Litwin, Ted D. Adams |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Bariatric Surgery Coronary Artery Disease medicine.disease_cause Article Coronary artery disease Calcinosis Weight loss Risk Factors Internal medicine Weight Loss medicine Humans Longitudinal Studies Prospective Studies Prospective cohort study Coronary atherosclerosis Nutrition and Dietetics Ejection fraction Gastric bypass surgery business.industry nutritional and metabolic diseases Middle Aged medicine.disease Surgery Obesity Morbid Blood pressure Echocardiography Research Design Cardiology Calcium Female medicine.symptom business Tomography X-Ray Computed Follow-Up Studies |
| Popis: | Obesity is associated with elevated coronary artery calcium (CAC), a marker of coronary atherosclerosis that is strongly predictive of cardiovascular events. We evaluated the effects of marked weight loss achieved through Roux-en-Y gastric bypass surgery (GBS) on CAC scores.We performed echocardiography and computed tomography of the heart in 149 subjects 6 years after enrollment in a prospective registry evaluating the cardiovascular effects of GBS. Coronary calcium scores, left ventricular ejection fraction, and left ventricular mass were measured.At baseline, most coronary risk factors were similar between the GBS and nonsurgical groups including current smoking, systolic blood pressure, LDL-C, HDL-C, and TG. However, GBS patients were younger (4.7 years), less likely to be diabetic, and less likely to be postmenopausal. At 6 years after enrollment, CAC score was significantly lower in patients who underwent GBS than those without surgery (p 0.01). GBS subjects had a lower likelihood of having measureable coronary calcium (odds ratio of CAC 0 = 0.39; 95 % CI of (0.17, 0.90)). Significant predictors of 0 CAC were GBS, female gender, younger age, baseline BMI, and baseline LDL-C. Substituting change in BMI for group status as a predictor variable showed that BMI change also predicted CAC (p = 0.045). Changes in LDL-C did not predict the CAC differences between groups (p = 0.67).Sustained weight loss achieved through bariatric surgery is associated with less coronary calcification. This effect, which appears to be independent of changes in LDL-C, may contribute to lower cardiac mortality in patients with successful GBS. |
| Databáze: | OpenAIRE |
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