Results of irradiation in patients with high-grade gliomas evaluated by magnetic resonance imaging
| Autor: | Baby Jose, William J. Spanos, R. B. Seither, Paris Kj, Robert D. Lindberg |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Cancer Research Adolescent medicine.medical_treatment Astrocytoma Central nervous system disease Radiotherapy High-Energy Glioma medicine Humans Survival rate Aged Retrospective Studies medicine.diagnostic_test business.industry Brain Neoplasms Magnetic resonance imaging Retrospective cohort study Middle Aged medicine.disease Combined Modality Therapy Magnetic Resonance Imaging nervous system diseases Radiation therapy Survival Rate Oncology Female business Nuclear medicine Glioblastoma Anaplastic astrocytoma |
| Zdroj: | American journal of clinical oncology. 18(4) |
| ISSN: | 0277-3732 |
| Popis: | Evidence shows that most high-grade gliomas are a diffuse process. Prior studies reported a median survival with surgery and postoperative radiotherapy of 8.6 months for glioblastoma multiforme (GBM) and 36.2 months for anaplastic astrocytoma (AA). Since MRI delineated the glioma better than CT scan, using MRI-based radiotherapy treatment planning allows for more precise treatment volumes. We retrospectively reviewed the records of the first 36 patients with malignant glioma, who had a presurgery MRI-based radiotherapy treatment planning. These patients were diagnosed between January 1986 and February 1991. Minimum follow up was 14 months and median survival was 15.4 months for GBM (7-42 months) and 27.4 months for AA (7-53 months). We feel that the trend for increased median survival in GBM (15.4 vs 8.6 months) is partly due to better definition of the tumor volume by using MRI. Larger studies are needed to confirm this finding. |
| Databáze: | OpenAIRE |
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