MetaTISA: Metagenomic Translation Initiation Site Annotator for improving gene start prediction
| Autor: | Huaiqiu Zhu, Yongchu Liu, Gangqing Hu, Jiangtao Guo |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Statistics and Probability
Supplementary data Source code media_common.quotation_subject Speech recognition Genomics Sequence Analysis DNA Computational biology Biology Biochemistry Genetic translation Computer Science Applications Computational Mathematics Genes Computational Theory and Mathematics Metagenomics Peptide Chain Initiation Translational Cluster analysis Molecular Biology Gene Phylogeny Software Translation initiation sites media_common |
| Zdroj: | Bioinformatics. 25:1843-1845 |
| ISSN: | 1367-4811 1367-4803 |
| Popis: | Summary: We proposed a tool named MetaTISA with an aim to improve TIS prediction of current gene-finders for metagenomes. The method employs a two-step strategy to predict translation initiation sites (TISs) by first clustering metagenomic fragments into phylogenetic groups and then predicting TISs independently for each group in an unsupervised manner. As evaluated on experimentally verified TISs, MetaTISA greatly improves the accuracies of TIS prediction of current gene-finders. Availability: The C++ source code is freely available under the GNU GPL license viahttp://mech.ctb.pku.edu.cn/MetaTISA/. Contact: hqzhu@pku.edu.cn Supplementary information: Supplementary data are available at Bioinformatics online. |
| Databáze: | OpenAIRE |
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