Agrin mediates a rapid switch from electrical coupling to chemical neurotransmission during synaptogenesis
| Autor: | Gérard Alonso, Agnès O. Martin, Nathalie C. Guérineau |
|---|---|
| Přispěvatelé: | Institut de Génomique Fonctionnelle (IGF), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Turner-Madeuf, Angela, Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2005 |
| Předmět: |
Aging
Patch-Clamp Techniques Time Factors [SDV]Life Sciences [q-bio] Chromaffin Cells acute slice Wistar Synaptogenesis Synaptic Transmission 0302 clinical medicine cholinergic synapses rat Cholinergic synapse Research Articles 0303 health sciences Agrin Gap junction Gap Junctions Cell Differentiation Up-Regulation [SDV] Life Sciences [q-bio] src-Family Kinases medicine.anatomical_structure stimulus-secretion coupling Cholinergic Fibers [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Female Acetylcholine medicine.drug medicine.medical_specialty Biology Neurotransmission Article Neuromuscular junction 03 medical and health sciences Organ Culture Techniques Internal medicine medicine Animals [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Rats Wistar 030304 developmental biology Splanchnic Nerves Cell Biology Newborn Rats Endocrinology Animals Newborn Adrenal Medulla Synapses Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Cell Biology Journal of Cell Biology Journal of Cell Biology, 2005, 169, pp.503-514. ⟨10.1083/jcb.200411054⟩ Journal of Cell Biology, Rockefeller University Press, 2005, 169, pp.503-514. ⟨10.1083/jcb.200411054⟩ |
| ISSN: | 1540-8140 0021-9525 |
| Popis: | In contrast to its well-established actions as an organizer of synaptic differentiation at the neuromuscular junction, the proteoglycan agrin is still in search of a function in the nervous system. Here, we report an entirely unanticipated role for agrin in the dual modulation of electrical and chemical intercellular communication that occurs during the critical period of synapse formation. When applied at the developing splanchnic nerve–chromaffin cell cholinergic synapse in rat adrenal acute slices, agrin rapidly modified cell-to-cell communication mechanisms. Specifically, it led to decreased gap junction–mediated electrical coupling that preceded an increase in nicotinic synaptic transmission. This developmental switch from predominantly electrical to chemical communication was fully operational within one hour and depended on the activation of Src family–related tyrosine kinases. Hence, agrin may play a pivotal role in synaptogenesis in promoting a rapid switch between electrical coupling and synaptic neurotransmission. |
| Databáze: | OpenAIRE |
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