Childhood adrenoleukodystrophy – Classic and variant – Review of clinical manifestations and magnetic resonance imaging
| Autor: | B. V. Suresh, Shrijeet Chakraborti, Mithun Sekhar, I G Bhat, P. V. Santosh Rai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry General Neuroscience Central nervous system Magnetic resonance imaging Disease medicine.disease Mr imaging Pathophysiology Hyperintensity medicine.anatomical_structure Pediatrics Perinatology and Child Health medicine Adrenal insufficiency magnetic resonance imaging Adrenoleukodystrophy Neuroimage business auditory pathway |
| Zdroj: | Journal of Pediatric Neurosciences |
| ISSN: | 1998-3948 1817-1745 |
| Popis: | Adrenoleukodystrophy (ALD) is a genetic disease associated with demyelination of the central nervous system, adrenal insufficiency, and accumulation of very long-chain fatty acids in tissue and body fluids. The attempt of this paper is to review the classical and not-so-classical MR imaging manifestations of adrenoleukodystrophy. A review of literature is done to describe the pathophysiology of the disease and the imaging differences between childhood and adult-onset of the disease. The literature is reviewed to explain the link with Addison's disease. In consensus the magnetic resonance imaging (MRI) findings of symmetrical occipital white matter lesions which progress in a rostro-caudal direction is the classical appearance of ALD. Familiarity with the clinico-pathologic manifestations and progressive MR imaging features of childhood cerebral X-linked ALD will be helpful in evaluating the affected patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|