Efficacy of 15-(123I)-p-iodophenyl pentadecanoic acid (IPPA) in assessing myocardial metabolism in a model of reversible global ischemia

Autor: Anne P. Autor, Hayes Dougan, Jan van den Broek, Eric W. R. Jamieson, Marla C. Kiess, Craig Sartori, Marck P. J. Hudon, Donald M. Lyster, Luis J. Rosado, Karim Qayumi
Rok vydání: 1988
Předmět:
Zdroj: European Journal of Nuclear Medicine. 14:594-599
ISSN: 1619-7089
0340-6997
DOI: 10.1007/bf00251782
Popis: In a canine model of reversible global ischemia, the residual quantity of 123I was assessed following a bolus injection of 15-p-(123I)-iodophenyl pentadecanoic acid (123I-IPPA). This technique was used to assess changes in free fatty acid metabolism following the utilization of three cardioplegic formulations. Cardioplegic arrest was initiated with Tyers' iso-osmolar (IO) solution (Group A); IO+superoxide dismutase (SOD) (Group B) and IO+allopurinol (Group C). Pre and post operative scanning were completed with 2–5 mCi 123I-IPPA. Clearance was assessed by IPPA time activity curve analysis generating t1/2 (half lives in min) for the early and late phases of the curve. The assessment between groups demonstrated that the elimination of 123I-IPPA products (early phase) was faster from the lateral wall in groups B and C versus group A (14±12 min, 13±9 min and 24±10 min, respectively). The elimination of IPPA (late phase) was also faster from the lateral wall in groups B and C when compared to group A (240±270 min, 132±85 min and 416±238 min). Examining the changes between control and postoperative values for each area of the left ventricle within each group demonstrated no significant, changes for groups B and C. Group A, however, demonstrated significantly increased t1/2 values for the lateral wall (early and late phases) and the apical wall (late phase). From this study it can be concluded that following 2 h of reversible global ischemia and reperfusion, the assessment of turnover of 123I-IPPA can be used to differentiate the effectiveness of various cardioplegic formulations. It appears that cardioplegic solutions supplemented with allopurinol and SOD (groups B and C) may be better able to protect myocardial fatty acid metabolism compared to Tyers' iso-osmolar solution (group A).
Databáze: OpenAIRE
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