Sex Hormones in Postmenopausal Women with Breast Cancer on Tamoxifen
| Autor: | V Alevizou-Terzaki, P Athanassiou, C Proukakis, I. Kostoglou-Athanassiou, E. Georgiou, J Gogas, K. Ntalles, C Markopoulos |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Antineoplastic Agents Hormonal Endocrinology Diabetes and Metabolism Breast Neoplasms Endocrinology Sex hormone-binding globulin Breast cancer Sex Hormone-Binding Globulin Internal medicine Humans Medicine Gonadal Steroid Hormones skin and connective tissue diseases Adverse effect Aged Aged 80 and over Estradiol biology business.industry Estrogen Antagonists Luteinizing Hormone Middle Aged medicine.disease Prolactin Menopause Tamoxifen biology.protein Female Follicle Stimulating Hormone business Luteinizing hormone hormones hormone substitutes and hormone antagonists Hormone medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1423-0046 0301-0163 |
| DOI: | 10.1159/000185445 |
| Popis: | In 42 postmenopausal women with breast cancer aged 48-85 (mean age 62.4) years, the blood sex hormone levels were measured before and after 6 months of tamoxifen administration (20 mg daily). Follicle-stimulating hormone and luteinizing hormone levels decreased after tamoxifen administration (p0.001), but remained in the postmenopausal range, oestradiol levels increased (p0.05), sex hormone binding globulin levels increased (p0.001), testosterone levels remained stable (p0.1), free testosterone levels decreased (p0.001), delta4-androstenedione, 17-hydroxyprogesterone, and dehydroepiandrosterone sulfate levels remained unchanged (p0.1), and basal prolactin levels and their response to thyrotrophin-releasing hormone injection decreased significantly (p0.001) after tamoxifen therapy. It is concluded that tamoxifen has many and diverse effects on sex hormone levels, and its adverse effects do not affect the biological status of the patient, except perhaps for oestradiol, that increases in some cases, whose possible effect must be studied. |
| Databáze: | OpenAIRE |
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