Involvement of transforming growth factor beta 1 in the transcriptional regulation of nicotinamide N-methyltransferase in clear cell renal cell carcinoma
| Autor: | Andrea B. Galosi, Stefania Fumarola, Valentina Pozzi, Monia Cecati, Veronica Pompei, Roberto Campagna, Giulio Milanese, Monica Emanuelli, Davide Sartini |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male STAT3 Transcription Factor Transcription Genetic Nicotinamide N-methyltransferase Kidney Metastasis Transforming Growth Factor beta1 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma medicine Biomarkers Tumor Nicotinamide N-Methyltransferase Humans STAT3 Carcinoma Renal Cell Aged Hepatocyte Nuclear Factor 1-beta Aged 80 and over biology business.industry Interleukin-6 General Medicine Transforming growth factor beta Middle Aged medicine.disease Kidney Neoplasms Gene Expression Regulation Neoplastic Clear cell renal cell carcinoma 030104 developmental biology 030220 oncology & carcinogenesis Cancer research biology.protein Hepatocyte Nuclear Factor 1-Beta Female business Clear cell |
| Zdroj: | Cellular and molecular biology (Noisy-le-Grand, France). 64(7) |
| ISSN: | 1165-158X |
| Popis: | Renal cell carcinoma (RCC) is the most common tumor of the kidney and its major histologic subtype is clear cell RCC (ccRCC). About 30% of diagnosed ccRCCs already have metastasis. Traditionally, localized ccRCC is treated with nephrectomy but the relapse rate is 30%. Thus, the discovery of effective biomarkers for early detection, as well as the identification of new targets for molecular-based therapy of ccRCC are urgently required. In this study, we focused on molecules that could modulate the trascription of the enzyme nicotinamide N-methyltransferase (NNMT) that is known to be up-regulated in ccRCC. Signal transducer and activator of transcription 3 (STAT3), interleukin 6 (IL-6), hepatocyte nuclear factor 1 beta (HNF-1β) and transforming growth factor beta 1 (TGF-β1) expression levels were determined in tumor and non tumor samples obtained from 30 patients with ccRCC, using Real-Time PCR. Results obtained showed that TGF-β1 is significantly (p |
| Databáze: | OpenAIRE |
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