Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications
| Autor: | Matthew L. Becker, Trenton Parsell, Zhaobo Fan, Chinnapatch Tantisuwanno, Zachary K. Zander, Molly C. Haines, Nathan Z. Dreger, Morgan Waggoner, Michael Hiles, Claus S. Sondergaard, Christopher Premanandan |
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| Rok vydání: | 2018 |
| Předmět: |
Hernia
Cell Survival Phenylalanine Polyesters Composite number Biophysics Biocompatible Materials Bioengineering 02 engineering and technology Cell Line Biomaterials Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo Elastic Modulus Absorbable Implants Materials Testing medicine Copolymer Animals Urea Fibroblast Herniorrhaphy chemistry.chemical_classification Polypropylene Valine 021001 nanoscience & nanotechnology Rats Amino acid medicine.anatomical_structure chemistry Mechanics of Materials 030220 oncology & carcinogenesis Ceramics and Composites 0210 nano-technology Nuclear chemistry |
| Zdroj: | Biomaterials. 182:44-57 |
| ISSN: | 0142-9612 |
| Popis: | The use of degradable materials is required to address current performance and functionality shortcomings from biologically-derived tissues and non-resorbable synthetic materials used for hernia mesh repair applications. Herein a series of degradable l -valine-co- l -phenylalanine poly(ester urea) (PEU) copolymers were investigated for soft-tissue repair . Poly[(1-VAL-8) 0.7-co-(1-PHE-6)0.3] showed the highest uniaxial mechanical properties (332.5 ± 3.5 MPa). Additionally, l -valine-co- l -phenylalanine poly(ester urea)s were blade coated on small intestine submucosa extracellular matrix (SIS-ECM) and found to enhance the burst test mechanical properties of SIS-ECM in composite films (force at break between 102.6 ± 6.5–151.4 ± 11.3 N). Free standing films of l -valine-co- l -phenylalanine PEUs were found to have superior extension at break when compared to SIS-ECM (averages between 1.2 and 1.9 cm and 1.2 cm respectively). Fibroblast (L-929) spreading, proliferation, and improved attachment over control were observed without toxicity in vitro, while a reduced inflammatory response at both 7 and 14 days post-implant was observed for poly[(1-VAL-8) 0.7-co-(1-PHE-6)0.3 ] when compared to polypropylene in an in vivo rat hernia model. These results support the use of PEU copolymers as free-standing films or as composite materials in soft-tissue applications for hernia-repair. |
| Databáze: | OpenAIRE |
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