Altered Cardiovascular Reactivity to and Recovery from Cold Face Test-Induced Parasympathetic Stimulation in Essential Hypertension
| Autor: | Petra H. Wirtz, Claudia Zuccarella-Hackl, Ulrike Ehlert, Roland von Känel, Lisa-Marie Walther, Nadja Heimgartner |
|---|---|
| Přispěvatelé: | University of Zurich, Wirtz, Petra H |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
hypertension Diastole Stimulation 2700 General Medicine 030204 cardiovascular system & hematology Essential hypertension Article parasympathetic stimulation Cold Face Test (CFT) cardiovascular reactivity chronic stress 03 medical and health sciences 0302 clinical medicine ddc:150 Internal medicine Heart rate medicine Chronic stress Reactivity (psychology) Relaxation (psychology) 10093 Institute of Psychology business.industry General Medicine medicine.disease 3. Good health 10057 Klinik für Konsiliarpsychiatrie und Psychosomatik Blood pressure Cardiology Medicine 150 Psychology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Medicine, Vol 10, Iss 2714, p 2714 (2021) Journal of Clinical Medicine Volume 10 Issue 12 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10122714 |
| Popis: | Essential hypertension is associated with increased sympathetic and diminished parasympathetic activity as well as impaired reactivity to sympathetic stimulation. However, reactivity and recovery from parasympathetic stimulation in hypertension are unknown. We investigated reactivity and recovery to primarily parasympathetic stimulation by Cold Face Test (CFT) in essential hypertension. Moreover, we tested whether chronic stress modulates CFT-reactivity dependent on hypertension status. The CFT was conducted by applying a cold face-mask for 2 min in 24 unmedicated, otherwise healthy hypertensive men and in 24 normotensive controls. Systolic and diastolic blood pressure (BP) and heart rate (HR) were measured repeatedly. Chronic stress was assessed with the Trier-Inventory-for-Chronic-Stress-Screening-Scale. Hypertensives did not exhibit diastolic BP decreases after CFT-cessation (p = 0.59) as did normotensives (p = 0.002) and failed to show HR decreases in immediate response to CFT (p = 0.62) when compared to normotensives (p < 0.001). Systolic BP reactivity and recovery patterns did not differ between hypertensives and normotensives (p = 0.44). Chronic stress moderated HR (p = 0.045) but not BP CFT-reactivity (p′s > 0.64) with chronically stressed normotensives showing similar HR reactivity as hypertensives. Our findings indicate impaired diastolic BP and HR reactivity to and recovery from CFT in hypertensives and a moderating effect of chronic stress on HR reactivity potentially reflecting reduced relaxation ability of the cardiovascular system. |
| Databáze: | OpenAIRE |
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