A Metabolomic Analysis of the Sex-Dependent Hispanic Paradox
| Autor: | Kristin J Farr, Ryan Eghlimi, Xiaojian Shi, William Bresette, Haiwei Gu, Sarah Atlas, Sonia Vega-López, Jeffrey Patterson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
obesity
endocrine system diseases Endocrinology Diabetes and Metabolism Physiology micronutrient intake Type 2 diabetes Microbiology Biochemistry Article Hispanic paradox Metabolomics medicine Metabolome LC-MS/MS Molecular Biology business.industry nutritional and metabolic diseases medicine.disease metabolomics Obesity QR1-502 macronutrient intake Blood pressure Analysis of variance business Body mass index |
| Zdroj: | Metabolites Volume 11 Issue 8 Metabolites, Vol 11, Iss 552, p 552 (2021) |
| ISSN: | 2218-1989 |
| DOI: | 10.3390/metabo11080552 |
| Popis: | In Mexican Americans, metabolic conditions, such as obesity and type 2 diabetes (T2DM), are not necessarily associated with an increase in mortality this is the so-called Hispanic paradox. In this cross-sectional analysis, we used a metabolomic analysis to look at the mechanisms behind the Hispanic paradox. To do this, we examined dietary intake and body mass index (BMI kg/m2) in men and women and their effects on serum metabolomic fingerprints in 70 Mexican Americans (26 men, 44 women). Although having different BMI values, the participants had many similar anthropometric and biochemical parameters, such as systolic and diastolic blood pressure, total cholesterol, and LDL cholesterol, which supported the paradox in these subjects. Plasma metabolomic phenotypes were measured using liquid chromatography tandem mass spectrometry (LC-MS/MS). A two-way ANOVA assessing sex, BMI, and the metabolome revealed 23 significant metabolites, such as 2-pyrrolidinone (p = 0.007), TMAO (p = 0.014), 2-aminoadipic acid (p = 0.019), and kynurenine (p = 0.032). Pathway and enrichment analyses discovered several significant metabolic pathways between men and women, including lysine degradation, tyrosine metabolism, and branch-chained amino acid (BCAA) degradation and biosynthesis. A log-transformed OPLS-DA model was employed and demonstrated a difference due to BMI in the metabolomes of both sexes. When stratified for caloric intake (< 2200 kcal/d vs. > 2200 kcal/d), a separate OPLS-DA model showed clear separation in men, while females remained relatively unchanged. After accounting for caloric intake and BMI status, the female metabolome showed substantial resistance to alteration. Therefore, we provide a better understanding of the Mexican-American metabolome, which may help demonstrate how this population—particularly women—possesses a longer life expectancy despite several comorbidities, and reveal the underlying mechanisms of the Hispanic paradox. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|