In vivo evidence of differential frontal cortex metabolic abnormalities in progressive and relapsing‐remitting multiple sclerosis
| Autor: | Katherine DeStefano, Hetty Prinsen, David Pitt, Christoph Juchem, Mary Lou P. Bailey, Robert K. Fulbright, Kelley M. Swanberg, Abhinav V. Kurada |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Glutamine gamma-Aminobutyric acid Choline Young Adult chemistry.chemical_compound Multiple Sclerosis Relapsing-Remitting In vivo Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Gray Matter gamma-Aminobutyric Acid Spectroscopy Aged Aspartic Acid Neurotransmitter Agents business.industry Multiple sclerosis Glutamate receptor Glutathione Middle Aged medicine.disease Pathophysiology Frontal Lobe Endocrinology chemistry Metabolome Molecular Medicine Female business Inositol medicine.drug |
| Zdroj: | NMR in Biomedicine. 34 |
| ISSN: | 1099-1492 0952-3480 |
| Popis: | The pathophysiology of progressive multiple sclerosis remains elusive, significantly limiting available disease-modifying therapies. Proton MRS (1 H-MRS) enables in vivo measurement of small molecules implicated in multiple sclerosis, but its application to key metabolites glutamate, γ-aminobutyric acid (GABA), and glutathione has been sparse. We employed, at 7 T, a previously validated 1 H-MRS protocol to measure glutamate, GABA, and glutathione, as well as glutamine, N-acetyl aspartate, choline, and myoinositol, in the frontal cortex of individuals with relapsing-remitting (N = 26) or progressive (N = 21) multiple sclerosis or healthy control adults (N = 25) in a cross-sectional analysis. Only individuals with progressive multiple sclerosis demonstrated reduced glutamate (F2,65 = 3.424, p = 0.04; 12.40 ± 0.62 mM versus control 13.17 ± 0.95 mM, p = 0.03) but not glutamine (F2,65 = 0.352, p = 0.7; 4.71 ± 0.35 mM versus control 4.84 ± 0.42 mM), reduced GABA (F2,65 = 3.89, p = 0.03; 1.29 ± 0.23 mM versus control 1.47 ± 0.25 mM, p = 0.05), and possibly reduced glutathione (F2,65 = 0.352, p = 0.056; 2.23 ± 0.46 mM versus control 2.51 ± 0.48 mM, p |
| Databáze: | OpenAIRE |
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