Synthetic Antibacterial Peptide Exhibits Synergy with Oxacillin against MRSA
| Autor: | John C. Lainson, Stephen Albert Johnston, Kathleen D. Triplett, Seth M. Daly, Pamela R. Hall, Chris W. Diehnelt |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.drug_class Antibiotics Peptide Biology Skin infection medicine.disease_cause 01 natural sciences Biochemistry Microbiology 03 medical and health sciences Drug Discovery medicine Pathogen chemistry.chemical_classification 010405 organic chemistry Organic Chemistry biochemical phenomena metabolism and nutrition Antimicrobial medicine.disease biology.organism_classification In vitro 0104 chemical sciences 030104 developmental biology chemistry Staphylococcus aureus Bacteria |
| Popis: | One proposed solution to the crisis of antimicrobial resistant (AMR) infections is the development of molecules that potentiate the activity of antibiotics for AMR bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Rather than develop broad spectrum compounds, we developed a peptide that could potentiate the activity of a narrow spectrum antibiotic, oxacillin. In this way, the combination treatment could narrowly target the resistant pathogen and limit impact on host flora. We developed a peptide, ASU014, composed of a S. aureus binding peptide and a S. aureus inhibitory peptide conjugated to a branched peptide scaffold, which has modest activity against S. aureus but exhibits synergy with oxacillin for MRSA both in vitro and in a MRSA skin infection model. The low concentration of ASU014 and sub-MIC concentration of oxacillin necessary for activity suggest that this molecule is a candidate for future medicinal chemistry optimization. |
| Databáze: | OpenAIRE |
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