Relationship between serotypes, age, and clinical presentation of invasive pneumococcal disease in Madrid, Spain, after introduction of the 7-valent pneumococcal conjugate vaccine into the vaccination calendar

Autor: J, Picazo, J, Ruiz-Contreras, J, Casado-Flores, E, Giangaspro, F, Del Castillo, T, Hernández-Sampelayo, E, Otheo, F, Balboa, E, Ríos, C, Méndez, L, Aguilar
Rok vydání: 2010
Předmět:
Serotype
Male
Heptavalent Pneumococcal Conjugate Vaccine
Serotypes
Clinical Biochemistry
medicine.disease_cause
Polymerase Chain Reaction
Pneumococcal conjugate vaccine
Pneumococcal Vaccines
Immunology and Allergy
Child
Vaccination
N-Acetylmuramoyl-L-alanine Amidase
Vaccine Research
Pneumococcal infections
Streptococcus pneumoniae
7-Valent Pneumococcal
Child
Preschool
Population Surveillance
Streptolysins
Female
Meningitis
medicine.drug
Microbiology (medical)
medicine.medical_specialty
Medicina
Immunology
Vaccination calendar
Pneumococcal disease
Pneumococcal Infections
Age
Age Distribution
Bacterial Proteins
Internal medicine
medicine
Humans
Serotyping
Immunization Schedule
business.industry
Infant
medicine.disease
bacterial infections and mycoses
Culture Media
Pneumonia
Spain
Bacteremia
business
Vaccine
Zdroj: Biblos-e Archivo. Repositorio Institucional de la UAM
instname
ISSN: 1556-679X
Popis: To assess invasive pneumococcal disease (IPD) clinical presentations and relationships with age and serotype in hospitalized children (ply ) and autolysin ( lyt ) gene PCR analysis. A total of 330 IPDs were identified: 263 (79.7%) confirmed by culture and 67 (20.3%) confirmed by PCR. IPD distribution by age (months) was as follows: 23.6% (59). Distribution by clinical presentation was as follows: 34.5% bacteremic pneumonia, 30.3% pediatric parapneumonic empyema (PPE), 13.6% meningitis, 13.3% primary bacteremia, and 8.2% others. Meningitis and primary bacteremia were the most frequent IPDs in children 36 months old. Frequencies of IPD-associated serotypes were as follows: 1, 26.1%; 19A, 18.8%; 5, 15.5%; 7F, 8.5%; 3, 3.9%; nontypeable/other 30 serotypes, 27.3%. Serotype 1 was linked to respiratory-associated IPD (38.6% in bacteremic pneumonia and 38.0% in PPE) and children of >36 months (51.4% for 36 to 59 months and 40.0% for >59 months), while serotype 19A was linked to nonrespiratory IPDs (31.1% in meningitis, 27.3% in primary bacteremia, and 51.9% in others) and children of
Databáze: OpenAIRE
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