Prognostic and predictive role of [18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with unresectable malignant pleural mesothelioma (MPM) treated with up-front pemetrexed-based chemotherapy

Autor: Arturo Chiti, Fabio De Vincenzo, Giovanni Luca Ceresoli, Gianluigi Ciocia, Cristiana Bonifacio, Emilio Bombardieri, Elena Lorenzi, Letizia Gianoncelli, Lucia Setti, Maria Bonomi, Armando Santoro, Egesta Lopci, Matteo Simonelli, Matteo Perrino, Laura Giordano, Paolo Andrea Zucali
Rok vydání: 2017
Předmět:
Male
Mesothelioma
Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
FDG‐PET
medicine.medical_treatment
Standardized uptake value
Kaplan-Meier Estimate
Pemetrexed
Gastroenterology
030218 nuclear medicine & medical imaging
Fluorodeoxyglucose positron emission tomography
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Chemotherapy
malignant pleural mesothelioma
Humans
Radiology
Nuclear Medicine and imaging
In patient
Pleurodesis
Original Research
Neoplasm Staging
prognostic role
medicine.diagnostic_test
business.industry
predictive role
Mesothelioma
Malignant
Clinical Cancer Research
Prognosis
medicine.disease
Treatment Outcome
Positron emission tomography
Positron-Emission Tomography
030220 oncology & carcinogenesis
Female
Tomography
X-Ray Computed
business
medicine.drug
Zdroj: Cancer Medicine
ISSN: 2045-7634
DOI: 10.1002/cam4.1182
Popis: The aim of this study was to evaluate the role of metabolic parameters analyzed at baseline and at interim FDG‐PET in predicting disease outcome in unresectable MPM patients receiving pemetrexed‐based chemotherapy. A consecutive series of MPM patients treated between February 2004 and July 2013 with first‐line pemetrexed‐based chemotherapy, and evaluated by FDG‐PET and CT scan at baseline and after two cycles of chemotherapy, was reviewed. Best CT scan response was assessed according to modified RECIST criteria. Progression‐free survival (PFS) and overall survival (OS) were correlated with FDG‐PET parameters, such as maximum standardized uptake value (SUVmax), total lesion glycolysis (TLG), and percentage changes in SUVmax (∆SUV) and TLG (∆TLG). Overall, 142 patients were enrolled; 77 (54%) received talc pleurodesis before chemotherapy. Baseline SUVmax and TLG showed a statistically significant correlation with PFS and OS (P
Databáze: OpenAIRE
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