Treatment of pulmonary epithelioid hemangioendothelioma with combination chemotherapy: Report of three cases and review of the literature
| Autor: | Jian Feng, Wang Li, Bo Ye, Bao‑Hui Han, Yong Chen, Jian‑Xin Shi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
medicine.medical_specialty Bevacizumab medicine.medical_treatment chemotherapy chemistry.chemical_compound medicine metastases Chemotherapy business.industry pulmonary tumors Cancer Combination chemotherapy Articles medicine.disease Carboplatin Surgery Thalidomide pulmonary epithelioid hemangioendothelioma Oncology chemistry Paclitaxel Radiology business medicine.drug Rare disease |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | No standard therapy for pulmonary epithelioid hemangioendothelioma (PEH) has yet been established due to the rarity of the disease, the lack of clear standards for treatment and the partial-to-complete spontaneous regression. This report describes three cases of PHE manifested as bilateral intrapulmonary masses with an initial diagnosis conducted by thoracoscopic lung biopsy. These patients demonstrated a partial response to combination chemotherapy with carboplatin, paclitaxel, bevacizumab or endostar, and an improvement in clinical status. Furthermore, we reviewed the literature regarding such patients who received chemotherapy and immunotherapy; this indicated that patients with PEH demonstrated a good partial response to chemotherapy with carboplatin, paclitaxel, bevacizumab, thalidomide and α-interferon. Overall, combination chemotherapy regimens may hold therapeutic potential for the treatment of this rare disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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