The effect of the molecular properties of calcium channel blockers on their elimination route
| Autor: | Biljana Stojimirovic, M Dejan Nesic, M Ratomir Jelic, V Jadranka Odovic, B Jasna Trbojevic-Stankovic |
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| Rok vydání: | 2015 |
| Předmět: |
Isradipine
Chemistry elimination route Nicardipine molecular weight nimodipine Pharmacology General Biochemistry Genetics and Molecular Biology 3. Good health lcsh:Biology (General) Calcium channel blockers Felodipine Linear regression lipophilicity medicine Nisoldipine Amlodipine Diltiazem General Agricultural and Biological Sciences lcsh:QH301-705.5 Nimodipine medicine.drug |
| Zdroj: | Archives of Biological Sciences Archives of Biological Sciences, Vol 67, Iss 3, Pp 801-806 (2015) |
| ISSN: | 1821-4339 0354-4664 |
| DOI: | 10.2298/abs150127039t |
| Popis: | Calcium channel blockers (CCBs) are among the most widely used drugs in cardiovascular medicine. In this study, nine CCBs (amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil and diltiazem) were investigated to assess the relationship between their molecular properties and elimination data obtained from literature. The descriptors of the molecular properties of CCBs were calculated using three software packages. The relationship between computed molecular properties and elimination data collected from relevant literature, initially investigated with simple linear regression analysis, showed poor correlation (R2 |
| Databáze: | OpenAIRE |
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