Feline Oral Squamous Cell Carcinoma: Clinical Manifestations and Literature Review
| Autor: | Melissa D. Sánchez, Lili Duda, Ozgur Bilgic, John R. Lewis |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Chemotherapy Palliative care General Veterinary business.industry medicine.medical_treatment Cat Diseases medicine.disease Radiation therapy Feline Oral Squamous Cell Carcinoma stomatognathic diseases medicine.anatomical_structure Tumor progression Tongue Carcinoma Squamous Cell Cats Carcinoma medicine Etiology Animals Mouth Neoplasms business |
| Zdroj: | Journal of Veterinary Dentistry. 32:30-40 |
| ISSN: | 2470-4083 0898-7564 |
| Popis: | Squamous cell carcinoma (SCC) is the most commonly encountered malignant oral tumor in cats. The etiology of this locally invasive tumor is likely multifactorial. Several risk factors have been identified, including the use of flea collars, and a history of feeding canned food and canned tuna. Clinical signs vary depending on tumor location. The tumor commonly arises from the gingiva and mucosa of the maxilla, mandible, tongue, sublingual area, or tonsillar region. Maxillary SCC commonly presents clinically as an ulcerative lesion, whereas mandibular SCC is commonly proliferative, expansile, and firm. Lingual/sublingual SCC may be ulcerative, necrotic, infiltrative, or proliferative. In general, feline oral SCC is an invasive and malignant neoplasm regardless of its location. Surgery, radiation therapy, chemotherapy and combinations thereof have been attempted with rarely a satisfactory response. Currently, cures are obtained only in a small subset of cats whose tumors are amenable to complete resection, or where resection with microscopic residual disease is followed by definitive radiation therapy. A multimodal treatment approach likely offers the best chance of success. For cats with advanced disease, palliative care may improve patients' quality of life, albeit transiently. Sequelae associated with tumor progression and local tissue destruction often result in euthanasia of feline patients with oral SCC. |
| Databáze: | OpenAIRE |
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