Serum levels of surfactant protein D predict the anti-tumor activity of gefitinib in patients with advanced non-small cell lung cancer

Autor: Minoru Fukuda, Nanae Tomonaga, Mineyo Takasu, Hirofumi Nakano, Hiroyuki Yamaguchi, Seiji Nagashima, Shigeru Kohno, Yoichi Nakamura, Hiroshi Soda, Seiji Doi, Tomayoshi Hayashi, Kazuhiro Tsukamoto, Hiroshi Takatani, Katsumi Nakatomi
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Adult
Male
Cancer Research
Lung Neoplasms
Antineoplastic Agents
Adenocarcinoma
Toxicology
Biomarkers
Pharmacological
Disease-Free Survival
Gefitinib
Pulmonary surfactant
Non-small cell lung cancer
Carcinoma
Non-Small-Cell Lung
Medicine
Humans
heterocyclic compounds
Pharmacology (medical)
In patient
skin and connective tissue diseases
Lung cancer
Protein Kinase Inhibitors
neoplasms
Aged
Pharmacology
Antitumor activity
Aged
80 and over
Polymorphism
Genetic
SP-A
Pulmonary Surfactant-Associated Protein A
business.industry
SP-D
Surfactant protein D
Middle Aged
medicine.disease
Prognosis
Pulmonary Surfactant-Associated Protein D
respiratory tract diseases
ErbB Receptors
Treatment Outcome
Oncology
Cancer research
Quinazolines
Female
Non small cell
business
Epidermal growth factor receptor tyrosine kinase
medicine.drug
Zdroj: Cancer chemotherapy and pharmacology. 67(2):331-338
ISSN: 0344-5704
Popis: PURPOSE: Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) that has dramatic effects in selective patients with non-small cell lung cancer (NSCLC). A simple non-invasive method for predicting the efficacy of gefitinib is preferable in clinical settings. In this study, we evaluated prospectively whether surfactant protein-A (SP-A) and -D (SP-D) may be new conventional predictors of the efficacy of gefitinib treatment. METHODS: We measured serum SP-A and SP-D levels on days 0 and 29 in 40 patients with advanced NSCLC treated with 250 mg gefitinib daily. Eligibility criteria included performance status
The original publication is available at www.springerlink.com
Cancer Chemotherapy and Pharmacology, 67(2), pp.331-338; 2011
Databáze: OpenAIRE
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