Area Under the Curve for Estradiol Levels Do Not Consistently Reflect Estradiol Levels on the Day of hCG Administration in Patients Undergoing Controlled Ovarian Hyperstimulation for IVF-ET
| Autor: | Ronald E. Batt, John Yeh, Michael W. Sullivan, Mohamed F.M. Mitwally, Hemlata S. Bhakoo, Kent Crickard |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Time Factors
Controlled ovarian hyperstimulation Fertilization in Vitro Biology Chorionic Gonadotropin Sensitivity and Specificity Andrology Ovarian Follicle Genetics medicine Humans In patient Ovarian follicle Genetics (clinical) Ivf outcome reproductive and urinary physiology Retrospective Studies Ivf treatment Estradiol urogenital system Area under the curve Obstetrics and Gynecology Retrospective cohort study General Medicine Embryo Transfer Embryo transfer medicine.anatomical_structure Assisted Reproduction Reproductive Medicine Area Under Curve Female hormones hormone substitutes and hormone antagonists Developmental Biology |
| Popis: | Purpose Most studies reported estradiol (E2) levels attained on day of hCG administration when investigating effect of E2 on IVF outcome. We studied whether a relationship exists between the area under the curve for E2 levels (AUC-E2) and E2 levels on hCG day during IVF-ET. Methods Retrospectively, we analyzed data for 313 patients who completed one IVF-ET cycle each. Patients were sorted according to AUC-E2 levels. Then we compared between each patient’s own AUC-E2 and the corresponding E2 level on hCG day for the same patient. Results Although overall AUC-E2 correlated positively with E2 levels on hCG day, there was no consistent correlation between individual patients. Conclusions AUC-E2 reflects more accurately the amount of E2 produced by the follicles during controlled ovarian hyperstimulation. The absence of a uniform correlation between AUC-E2 and E2 on hCG day may result in different conclusions when studying outcomes of IVF treatment. |
| Databáze: | OpenAIRE |
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