Narcolepsy: Cholinergic receptor changes in an animal model
| Autor: | Theodore L. Baker, Jack D. Barchas, Ivan N. Mefford, Richard E. Boehme, William C. Dement, Roland D. Ciaranello |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Cataplexy Biology General Biochemistry Genetics and Molecular Biology Dogs Animal model Internal medicine Muscarinic acetylcholine receptor medicine Animals Humans Tissue Distribution General Pharmacology Toxicology and Pharmaceutics Receptor Narcolepsy Acetylcholine receptor Brain General Medicine medicine.disease Receptors Muscarinic Endocrinology Forebrain Brainstem medicine.symptom Neuroscience |
| Zdroj: | Life Sciences. 34:1825-1828 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(84)90675-1 |
| Popis: | An inbred colony of narcoleptic doberman pinschers has been analyzed for muscarinic receptor levels in 19 discrete brain regions. In comparison to age-matched controls, receptors were generally elevated in the brainstem and reduced in forebrain areas. No changes in receptor binding affinity were detected. The increased receptor levels found in the brainstem suggest that cholinoceptive neurons in this region are hypersensitive and may be involved in the initiation of cataplexy and other aspects of the narcolepsy syndrome. |
| Databáze: | OpenAIRE |
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