The effect of cannabinoids on dinitrofluorobenzene-induced experimental asthma in mice
| Autor: | Yesim Kaya, Sevgen Onder, Inci Sahin-Erdemli, Nezahat Tugba Durlu-Kandilci, Turgut Emrah Bozkurt |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Agonist Atropine Serotonin Contraction (grammar) Carbachol Cannabinoid receptor Physiology medicine.drug_class medicine.medical_treatment Tetrodotoxin Pharmacology Receptor Cannabinoid CB2 03 medical and health sciences Mice Dinitrofluorobenzene Receptor Cannabinoid CB1 In vivo medicine Animals Anti-Asthmatic Agents Cannabinoid Receptor Agonists Dose-Response Relationship Drug Chemistry Cannabinoids General Neuroscience Macrophages respiratory system Acetylcholine Asthma Electric Stimulation Trachea Disease Models Animal 030104 developmental biology Immunology Female Cannabinoid medicine.drug |
| Zdroj: | Respiratory physiologyneurobiology. 231 |
| ISSN: | 1878-1519 |
| Popis: | Cannabinoids have anti-inflammatory effects and can produce bronchodilation in the airways. We have investigated the effects of cannabinoids on tracheal hyperreactivity and airway inflammation in dinitrofluorobenzene (DNFB)-induced experimental non-atopic asthma in mice. 5-hydroxytryptamine (5-HT)-induced contraction response was enhanced while carbachol- and electrical field stimulation-induced contractions, and isoprenaline-induced relaxation responses were remained unchanged in DNFB group. The increased 5-HT-induced contractions were inhibited by incubation with either atropine or tetrodotoxin. DNFB application resulted in increased macrophage number in the bronchoalveolar lavage fluid (BALF). In vivo ACEA (CB1 agonist) treatment prevented the increase in 5-HT contractions, while JWH133 (CB2 agonist) had no effect. However, neither ACEA nor JWH133 prevented the increase in macrophage number in BALF. In vitro ACEA incubation also inhibited the increase in 5-HT contraction in DNFB group. These results show that cannabinoid CB1 receptor agonist can prevent tracheal hyperreactivity to 5-HT in DNFB-induced non-atopic asthma in mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect