Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease
| Autor: | Marc Ferrante, Ingrid Arijs, Leentje Van Lommel, Gert De Hertogh, Jan Van der Goten, Kris Nys, Gert Van Assche, Paul Rutgeerts, Sebastiaan De Schepper, Severine Vermeire, Anica Schraenen, Wiebe Vanhove, Dominiek Staelens, Paul Peeters, Emiel F.M. Wouters, Frans Schuit, Isabelle Cleynen, Niki L. Reynaert |
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| Přispěvatelé: | Pulmonologie, RS: CAPHRI School for Public Health and Primary Care, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, RS: CAPHRI - R5 - Optimising Patient Care |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Transcriptional Activation GENE ATG16L1 Inflammasomes Biopsy PATHOGENESIS Caspase 1 Inflammation Biology Inflammatory bowel disease NLRP3 INFLAMMASOME ACTIVATION Cohort Studies AIM2 Intestinal mucosa Downregulation and upregulation INFLIXIMAB medicine Immunology and Allergy Humans HMGB1 Protein Intestinal Mucosa METAANALYSIS Aged Innate immune system Gastroenterology Nuclear Proteins Inflammasome Epithelial Cells DNA ASSOCIATION Middle Aged medicine.disease Inflammatory Bowel Diseases Phosphoproteins digestive system diseases CROHNS-DISEASE Immunity Innate Up-Regulation DNA-Binding Proteins Case-Control Studies Immunology AUTOPHAGY Female medicine.symptom medicine.drug Signal Transduction |
| Zdroj: | Inflammatory Bowel Diseases, 21(11), 2673-2682. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 1536-4844 1078-0998 |
| Popis: | BACKGROUND: Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gut, partly driven by defects in the innate immune system. Considering the central role of inflammasome signaling in innate immunity, we studied inflammasome components in IBD mucosa. METHODS: Expression of genes encoding inflammasome sensor subunits was investigated in colonic mucosal biopsies from 2 cohorts of patients with IBD and controls. RESULTS: A significant upregulation (>2-fold change in expression, false discovery rate |
| Databáze: | OpenAIRE |
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