Long-term risk of adverse outcomes according to atrial fibrillation type
| Autor: | Steffen Blum, Stefanie Aeschbacher, Michael Coslovsky, Pascal B. Meyre, Philipp Reddiess, Peter Ammann, Paul Erne, Giorgio Moschovitis, Marcello Di Valentino, Dipen Shah, Jürg Schläpfer, Rahel Müller, Jürg H. Beer, Richard Kobza, Leo H. Bonati, Elisavet Moutzouri, Nicolas Rodondi, Christine Meyer-Zürn, Michael Kühne, Christian Sticherling, Stefan Osswald, David Conen, the BEAT-AF and Swiss-AF investigators |
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| Přispěvatelé: | Clinical sciences |
| Rok vydání: | 2022 |
| Předmět: |
Male
Science Embolism Myocardial Infarction atrial fibrillation type Long-term risk 610 Medicine & health Hemorrhage adverse outcomes Comorbidity Cohort Studies 360 Social problems & social services Risk Factors Cause of Death Atrial Fibrillation Humans Prospective Studies Aged Proportional Hazards Models Aged 80 and over Heart Failure Multidisciplinary Incidence Middle Aged Hospitalization Stroke Medicine Female Cardiology and Cardiovascular Medicine Switzerland Follow-Up Studies |
| Zdroj: | Blum, Steffen; Aeschbacher, Stefanie; Coslovsky, Michael; Meyre, Pascal B; Reddiess, Philipp; Ammann, Peter; Erne, Paul; Moschovitis, Giorgio; Di Valentino, Marcello; Shah, Dipen; Schläpfer, Jürg; Müller, Rahel; Beer, Jürg H; Kobza, Richard; Bonati, Leo H; Moutzouri, Elisavet; Rodondi, Nicolas; Meyer-Zürn, Christine; Kühne, Michael; Sticherling, Christian; ... (2022). Long-term risk of adverse outcomes according to atrial fibrillation type. Scientific reports, 12(1), p. 2208. Springer Nature 10.1038/s41598-022-05688-9 Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022) |
| DOI: | 10.48350/165476 |
| Popis: | Sustained forms of atrial fibrillation (AF) may be associated with a higher risk of adverse outcomes, but few if any long-term studies took into account changes of AF type and co-morbidities over time. We prospectively followed 3843 AF patients and collected information on AF type and co-morbidities during yearly follow-ups. The primary outcome was a composite of stroke or systemic embolism (SE). Secondary outcomes included myocardial infarction, hospitalization for congestive heart failure (CHF), bleeding and all-cause mortality. Multivariable adjusted Cox proportional hazards models with time-varying covariates were used to compare hazard ratios (HR) according to AF type. At baseline 1895 (49%), 1046 (27%) and 902 (24%) patients had paroxysmal, persistent and permanent AF and 3234 (84%) were anticoagulated. After a median (IQR) follow-up of 3.0 (1.9; 4.2) years, the incidence of stroke/SE was 1.0 per 100 patient-years. The incidence of myocardial infarction, CHF, bleeding and all-cause mortality was 0.7, 3.0, 2.9 and 2.7 per 100 patient-years, respectively. The multivariable adjusted (a) HRs (95% confidence interval) for stroke/SE were 1.13 (0.69; 1.85) and 1.27 (0.83; 1.95) for time-updated persistent and permanent AF, respectively. The corresponding aHRs were 1.23 (0.89, 1.69) and 1.45 (1.12; 1.87) for all-cause mortality, 1.34 (1.00; 1.80) and 1.30 (1.01; 1.67) for CHF, 0.91 (0.48; 1.72) and 0.95 (0.56; 1.59) for myocardial infarction, and 0.89 (0.70; 1.14) and 1.00 (0.81; 1.24) for bleeding. In this large prospective cohort of AF patients, time-updated AF type was not associated with incident stroke/SE. |
| Databáze: | OpenAIRE |
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