The Effect of Radioactive Iodine Treatment on 14C Urea Breath Test Results in Patients with Hyperthyroidism
| Autor: | Irfan Peksoy, Bercem Aycicek Dogan, Ufuk Ozuguz, Ayse Arduc, Mazhar Muslim Tuna, Dilek Berker, Yusuf Aydin, Serhat Isik, Serdar Güler, Ferhat Gokay, Yasemin Tutuncu |
|---|---|
| Přispěvatelé: | Hitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü |
| Rok vydání: | 2014 |
| Předmět: |
Male
Helicobacter pylori infection medicine.medical_specialty Urea breath test Hyperthyroidism Gastroenterology Helicobacter Infections Iodine Radioisotopes Antithyroid Agents Antimicrobial effect Internal medicine medicine Humans Urea Radiology Nuclear Medicine and imaging In patient Carbon Radioisotopes Prospective Studies Prospective cohort study Methimazole Helicobacter pylori medicine.diagnostic_test business.industry Stomach Thyroid General Medicine Middle Aged radioactive iodine therapy medicine.anatomical_structure Endocrinology Breath Tests 14C Urea Breath Test C-14 urea breath test Female Radioactive iodine business |
| Zdroj: | Clinical Nuclear Medicine. 39:1022-1026 |
| ISSN: | 0363-9762 |
| DOI: | 10.1097/rlu.0000000000000519 |
| Popis: | Purpose: Radioactive 131Iodine therapy (RAIT) plays a major role in the treatment of hyperthyroidism. In addition to the thyroid gland, significant amounts of radioactive iodine are maintained in the stomach. The aim of this study was to determine if RAIT has any effect on Helicobacter pylori infection, based on the 14C urea breath test (UBT). Materials and Methods: The study included 85 patients with hyperthyroidism scheduled to undergo RAIT and 69 hyperthyroid subjects in whom methimazole treatment was planned. All subjects had pretreatment-positive UBT results, and the test was repeated on the first and third months after RAIT and methimazole treatment. Results: After a mean RAIT dose of 15 mCi (range, 10Y20 mCi), UBT became negative in 13 (15.3%) of 85 patients on the first month and 18 (21.2%) of 85 patients on the third month. All subjects treated with methimazole remained UBT positive on the first and third months of methimazole treatment (100%). Reduction in the number of UBT-positive patients on both the first and the third months after RAITwas statistically significant (P G 0.001). Distribution of hyperthyroidism etiologies and thyroid autoantibody levels in subjects with UBT that became negative and in subjects with UBT that remained positive were similar in the RAIT group (P 9 0.05). Urea breath test negativity rates did not differ according to the radioiodine dose. Conclusions: Our findings indirectly showed that RAIT might have an antimicrobial effect on H. pylori. Clinical applications of this beneficial effect of RAITon H. pylori should be further evaluated. Copyright © 2014 by Lippincott Williams & Wilkins. |
| Databáze: | OpenAIRE |
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