Light-induced antibacterial activity of electrospun chitosan-based material containing photosensitizer
| Autor: | Kathrin Smuda, Aleš Lapanje, Radostina Georgieva, Alexey M. Yashchenok, A N Severyukhina, Daniil N. Bratashov, N.A. Yurasov, D.M. Puchinyan, Hans Bäumler, I.A. Mamonova, Dmitry A. Gorin, N V Petrova |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Light medicine.drug_class medicine.medical_treatment Antibiotics Biocompatible Materials Bioengineering Photodynamic therapy Microbial Sensitivity Tests 02 engineering and technology Spectrum Analysis Raman 010402 general chemistry medicine.disease_cause 01 natural sciences Microbiology Biomaterials Chitosan chemistry.chemical_compound medicine Photosensitizer Particle Size Photosensitizing Agents Tissue Engineering Tissue Scaffolds Prepared Material 021001 nanoscience & nanotechnology Antimicrobial Anti-Bacterial Agents 0104 chemical sciences chemistry Mechanics of Materials Staphylococcus aureus 0210 nano-technology Antibacterial activity |
| Zdroj: | Materials Science and Engineering: C. 70:311-316 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2016.09.005 |
| Popis: | Increasing antimicrobial resistance requires the development of novel materials and approaches for treatment of various infections. Utilization of photodynamic therapy represents an advanced alternative to antibiotics and metal-based agents. Here, we report the fabrication of electrospun material that possesses benefits of both topical antimicrobial and photodynamic therapies. This material combines chitosan, as a biocompatible polymer, and a second generation photosensitizer. The incorporation of photosensitizer doesn't affect the material morphology and its nearly uniform distribution in fibers structure was observed by confocal Raman microscopy. Owing to photosensitizer the prepared material exhibits the light-induced and spatially limited antimicrobial activity that was demonstrated against Staphylococcus aureus, an important etiological infectious agent. Such material can be potentially used in antibacterial therapy of chronic wounds, infections of diabetic ulcers, and burns, as well as rapidly spreading and intractable soft-tissue infections caused by resistant bacteria. |
| Databáze: | OpenAIRE |
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