The evaluation of a new animal method for the prediction of clinical anti-depressant activity
| Autor: | E. Bindler, I. Sanghvi, Samuel Gershon |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Pathology
medicine.medical_specialty Imipramine Behavior Animal business.industry Yohimbine Blood Pressure Drug Synergism General Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Antidepressive Agents Dogs Injections Intravenous medicine Methods Animals Anti depressant General Pharmacology Toxicology and Pharmaceutics business |
| Zdroj: | Life sciences. 8(1) |
| ISSN: | 0024-3205 |
| Popis: | A new animal method has been evaluated to predict clinically useful anti-depressant agents. The test relies on the potentiating effects of anti-depressants on the behavioral and physiological changes induced by YOH in the conscious dog. Two agents, BL-KR 140 and EXP-561, which were predicted to be useful anti-depressant agents from the animal tests, failed to potentiate YOH induced changes, unlike IMI. Clinically also they were found to lack any anti-depressant activity. It is proposed that this test should be further evaluated employing established and potential anti-depressant agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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