Ropivacaine in the horse: its pharmacological responses, urinary detection and mass spectral confirmation
| Autor: | L. Dirikolu, Thomas Tobin, Andreas F. Lehner, J. Boyles, J. D. Harkins, W. G. Carter, W. Karpiesiuk, W. E. Woods |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.drug_class
Urinary system Metabolite Mepivacaine Enzyme-Linked Immunosorbent Assay Urine Pharmacology Sensitivity and Specificity Mass Spectrometry chemistry.chemical_compound medicine Animals Ropivacaine Horses Anesthetics Local Dose-Response Relationship Drug General Veterinary Local anesthetic Horse Amides chemistry Anesthesia Elisa test medicine.drug |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 24:89-98 |
| ISSN: | 1365-2885 0140-7783 |
| DOI: | 10.1046/j.1365-2885.2001.00314.x |
| Popis: | This report evaluates the pharmacological responses, urinary detection and mass spectral confirmation of ropivacaine in horses. Ropivacaine, a potent local anesthetic (LA) recently introduced in human medicine, has an estimated highest no-effect dose (HNED) of about 0.4 mg/site as determined in our abaxial sesamoid block model. Apparent ropivacaine equivalents were detectable by ELISA screening using a mepivacaine ELISA test after administration of clinically effective doses. Mass spectral examination of postadministration urine samples showed no detectable parent ropivacaine, but a compound indistinguishable from authentic 3-hydroxyropivacaine was recovered from these samples. The study shows that ropivacaine is a potent LA in the horse, that clinically effective doses can be detected in postadministration samples by ELISA-based screening, and that its major post administration urinary metabolite is 3-hydroxyropivacaine. |
| Databáze: | OpenAIRE |
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