Effects of Synbiotic Supplementation and Lifestyle Modifications on Women With Polycystic Ovary Syndrome
| Autor: | Barbara Zwozdziak, Martyna Siakowska, Izabela Chudzicka-Strugała, Anna Kubiak, Antoni J. Duleba, Beata Banaszewska, Leszek Pawelczyk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism Clinical Biochemistry Synbiotics 030209 endocrinology & metabolism Context (language use) Overweight Placebo Biochemistry Body Mass Index 03 medical and health sciences 0302 clinical medicine Endocrinology Double-Blind Method Weight loss Internal medicine medicine Humans Testosterone Life Style 030109 nutrition & dietetics business.industry Biochemistry (medical) Testosterone (patch) Polycystic ovary Dietary Supplements Female medicine.symptom business Body mass index Polycystic Ovary Syndrome |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 106:2566-2573 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgab369 |
| Popis: | Context Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Objective This study was designed to evaluate effects of lifestyle modifications and synbiotic supplementation on PCOS. Design A randomized (1:1) double-blind, placebo-controlled trial. Setting Academic hospital. Patients or Other Participants Overweight and obese women with PCOS were identified according to the Rotterdam criteria. Evaluations were performed at baseline and repeated after 3 months of treatment. Intervention Lifestyle modifications in combination with synbiotic supplementation or placebo. Main Outcome Measures Change in body mass index (BMI) and testosterone level. Results In the placebo group, a 5% decrease in BMI was accompanied by significant decreases of the waist, hip, and thigh circumferences. The synbiotic group experienced an 8% decrease in BMI, which was significantly greater than that in the control group (P = 0.03) and was accompanied by decreases in the waist, hip, and thigh circumferences. Testosterone did not decrease significantly in the placebo group (decrease of 6%), whereas in the synbiotic group it decreased by 32% (P < 0.0001). The decrease of testosterone was significantly greater in the synbiotic group than in the placebo group (P = 0.016). Conclusions Synbiotic supplementation potentiated effects of lifestyle modifications on weight loss and led to significant reduction of serum testosterone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|