FAT10 level in human gastric cancer and its relation with mutant p53 level, lymph node metastasis and TNM staging
| Autor: | Xi Jin, Yue-liang Chen, Qin-Wei Xu, Feng Ji, Zi-wei Wang, Chun-hua Jiao |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Mutant macromolecular substances medicine.disease_cause Metastasis Pathogenesis Young Adult Stomach Neoplasms Biomarkers Tumor medicine Humans Stage (cooking) Ubiquitins Survival rate Aged Neoplasm Staging Aged 80 and over business.industry musculoskeletal neural and ocular physiology digestive oral and skin physiology Gastroenterology Cancer General Medicine Middle Aged Prognosis medicine.disease digestive system diseases Survival Rate Orignal Articles nervous system Lymphatic Metastasis Cancer research Immunohistochemistry Female Tumor Suppressor Protein p53 Carcinogenesis business |
| Zdroj: | World Journal of Gastroenterology. 15:2228 |
| ISSN: | 1007-9327 |
| Popis: | AIM: To investigate the role of FAT10 and mutant p53 in the pathogenesis, severity and prognosis of gastric cancer. METHODS: FAT10, mutant p53 mRNA and protein levels were measured by reverse transcription (RT)-PCR and immunohistochemistry in gastric cancer tissue (n = 62), tumor-adjacent tissue (n = 62) and normal gastric tissue (n = 62). Relation of FAT10 and mutant p53 expression with clinicopathological features and clinical outcomes of gastric cancer patients were analyzed. RESULTS: The FAT10, mutant p53 mRNA and protein levels were significantly higher in gastric cancer than in its adjacent and normal tissue. The FAT10 and mutant p53 levels in gastric cancer tissue were significantly correlated with lymph node metastasis and tumor, nodes, metastasis (TNM) staging. Moreover, the high FAT10 level was associated with the overall survival rate of patients. Multivariate Cox-proportional hazards model analysis showed that mRNA and protein levels of FAT10 and mutant p53, lymph node metastasis, distant metastasis and TNM stage were the independent prognostic factors for gastric cancer. CONCLUSION: FAT10 may be involved in gastric carcinogenesis, and is a potential marker for the prognosis of gastric cancer patients. FAT10 and mutant p53 may play a common role in the carcinogenesis of gastric cancer. |
| Databáze: | OpenAIRE |
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