Vitamin D Status, Insulin Resistance, Leptin-To-Adiponectin Ratio in Adolescents: Results of a 1-Year Lifestyle Intervention
| Autor: | F.-L. Velayoudom-Cephise, Jean Plumasseau, Elodie Bouaziz-Amar, Josiane Clepier, Christophe Armand, Christine Rambhojan, Anne Blanchet-Deverly, Lydia Foucan, Laurent Larifla, Jean-Marc Lacorte |
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| Přispěvatelé: | Equipe de recherche sur le Risque Cardio métabolique, Université des Antilles et de la Guyane (UAG), Réseau GRANDIR, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Centre d’Examens de Santé, AGREXAM, Guadeloupe, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), This study was partly supported by grants from the University Hospital of Guadeloupe, France. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Lifestyle intervention
medicine.medical_specialty Adipokine lcsh:Medicine 030209 endocrinology & metabolism Adolescents vitamin D deficiency 03 medical and health sciences 0302 clinical medicine Insulin resistance Endocrinology Basic Science Internal medicine medicine Vitamin D and neurology 030212 general & internal medicine Leptin-to-adiponectin ratio 2. Zero hunger Vitamin D deficiency Adiponectin business.industry Leptin Incidence (epidemiology) lcsh:R General Medicine medicine.disease Obesity 3. Good health Medicine business [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences Open Access Macedonian Journal of Medical Sciences, 2016, 4 (4), pp.596-602 Open Access Macedonian Journal of Medical Sciences, Vol 4, Iss 4, Pp 596-602 (2016) Open Access Macedonian Journal of Medical Sciences; Vol. 4 No. 4 (2016): Dec 15 (OAMJMS); 596-602 Open Access Macedonian Journal of Medical Sciences; Vol 4, No 4 (2016): Dec 15 (OAMJMS); 596-602 |
| ISSN: | 1857-9655 |
| Popis: | AIM: We aimed to study the relationships between circulating 25-hydroxyvitamin D [25(OH)D], insulin resistance and leptin-to-adiponectin (L/A) ratio in Guadeloupean children and adolescents and to analyse the changes in 25(OH)D levels after a 1-year lifestyle intervention program.METHODS: 25(OH)D concentrations were measured via a chemiluminescence assay. Cardiometabolic risk factors, homoeostasis model assessment of insulin resistance (HOMA-IR), and adipokines were measured. The lifestyle intervention included dietary counselling, regular physical activity.RESULTS: Among 117 girls and boys (11–15 years old, 31.6% obese), 40% had vitamin D deficiency (25(OH)D levels < 20 ng/mL). With linear regression models where 25(OH)D and HOMA-IR acted as independent variables and age, sex, BMI, L/A ratio as covariates, 25(OH)D was significantly associated with HOMA-IR alone (P = 0.036). HOMA-IR was also associated with BMI z-score ≥ 2, L/A ratio and an interaction term BMI z-score ≥ 2*L/A ratio (P < 0.001 for all). After one year, in 78 children/adolescent, mean serum 25(OH)D increased significantly from 21.4 ± 4.9 ng/mL at baseline to 23.2 ± 6.0 after 1 year; P = 0.003 whereas BMI z-score, HOMA-IR and L/A ratio decreased significantly (P = 0.003, P < 0.001 and P = 0.012; respectively).CONCLUSION: The association between 25(OH)D and HOMA-IR, independently of obesity and the high prevalence of vitamin D deficiency should be considered in order to prevent the later incidence of T2DM. A healthy lifestyle including non-sedentary and outdoor activities could be a way for improving vitamin D status. |
| Databáze: | OpenAIRE |
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