Cycloplatinated(II) Derivatives of Mercaptopurine Capable of Binding Interactions with HSA/DNA

Autor:	Marzieh Dadkhah Aseman, Bahram Hemmateenejad, Shiva Aryamanesh, S. Masoud Nabavizadeh, Zahra Shojaeifard
Rok vydání:	2019
Předmět:	Organoplatinum Compounds Stereochemistry Antineoplastic Agents Serum Albumin Human 010402 general chemistry 01 natural sciences Inorganic Chemistry Structure-Activity Relationship chemistry.chemical_compound Deprotonation medicine Humans Physical and Theoretical Chemistry Density Functional Theory Cell Proliferation Binding Sites Dose-Response Relationship Drug Molecular Structure Mercaptopurine 010405 organic chemistry Chemistry DNA 0104 chemical sciences Molecular Docking Simulation Thermodynamics Drug Screening Assays Antitumor K562 Cells medicine.drug
Zdroj:	Inorganic Chemistry. 58:16154-16170
ISSN:	1520-510X 0020-1669
DOI:	10.1021/acs.inorgchem.9b02696
Popis:	In this study, two new bis-cyclometalated Pt(II) complexes, [Pt(C^N)(S^N)] [S^N = deprotonated 6-mercaptopurine (6-MP) and C^N = deprotonated 2-phenylpyridine (ppy), 2a; C^N = deprotonated benzo[h]...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ebc91632e41d40a7d513e3e8715609 https://doi.org/10.1021/acs.inorgchem.9b02696 Zobrazit plný text záznamu