X gene/core promoter deletion mutation: A novel mechanism leading to hepatitis B ‘e’ antigen-negative chronic hepatitis B
| Autor: | Mei-Ya Chen, Hongzhi Xu, Hong-Min Xiao, Jing Dong, Zhi-Ping Zhang, Fei Zhou, Ya-pi Lu, Jian-Lin Ren |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Hepatitis B virus Cancer Research Molecular Sequence Data Mutant Biology medicine.disease_cause Biochemistry Virus Hepatitis B Chronic Antigen Genetics medicine Humans Viral Regulatory and Accessory Proteins Amino Acid Sequence Hepatitis B e Antigens Promoter Regions Genetic Molecular Biology Mutation virus diseases Promoter Middle Aged Hepatitis B medicine.disease Virology digestive system diseases Oncology HBeAg Hepatocellular carcinoma DNA Viral Trans-Activators Molecular Medicine Female |
| Zdroj: | Molecular Medicine Reports. 10:799-803 |
| ISSN: | 1791-3004 1791-2997 |
| DOI: | 10.3892/mmr.2014.2248 |
| Popis: | Mutations in the precore and core promoter regions of hepatitis B 'e' antigen (HBeAg) are implicated in HBeAg‑negative chronic hepatitis B virus (HBV) infection (CHB). The objective of the current study was to investigate novel mutant patterns that lead to HBeAg‑negative CHB. The . PreX-X genomic region from the sera of HBV‑infected patients was amplified, and analysis of the sequences displayed a unique deletion region, 234 nucleotides in length, which was observed in 54 clones and named core promoter deletion (CPD). CPD may have an important role in the cause of HBeAg‑negative CHB. In addition, a novel deletion mutation in the X gene was observed in patients with CHB. This deletion mutant codes a 76‑amino‑acid X factor instead of the X protein. In the present study, a new mutation pattern was discovered that may contribute to the cause of HBeAg-negative CHB, and therefore it is worthy of future studies. |
| Databáze: | OpenAIRE |
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