Evaluation of antinociceptive effect of Petiveria alliacea (guiné) in animals
| Autor: | Reinaldo N. Takahashi, Gina Struffaldi Morato, Thereza Christina Monteiro de Lima |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Microbiology (medical)
Male lcsh:Arctic medicine. Tropical medicine medicine.drug_class lcsh:RC955-962 Analgesic central pharmacological actions lcsh:QR1-502 crude aqueous extract Pharmacology Motor Activity lcsh:Microbiology Mice antinociceptive thresholds medicine Animals Hypnotics and Sedatives Rats Wistar Petiveria alliacea Pain Measurement Analgesics biology business.industry Plant Extracts biology.organism_classification Phytolaccaceae Hypertonic saline Rats Nociception Sedative Antispasmodic Anticonvulsants Female business Acetylcholine medicine.drug |
| Zdroj: | Memórias do Instituto Oswaldo Cruz, Volume: 86 Supplement 2, Pages: 153-158, Published: 1991 Memórias do Instituto Oswaldo Cruz., Vol 86, Pp 153-158 (1991) |
| Popis: | Petiveria alliacea (Phytolaccaceae) is a bush widely distributed in South America including Brazil, where it is popularly known as "guiné", "pipi", "tipi" or "erva-de-tipi". Brazilian folk medicine attributes to the hot water infusion of its roots or leaves the following pharmacological properties: antipyretic, antispasmodic, abortifacient, antirrheumatic, diuretic, analgesic and sedative. The present study has evaluated the alleged effects of P. alliacea on central nervous system (CNS), particularly, the sedative and analgesic properties of root crude aqueous extract of this plant in mice and rats. This extract showed an antinociceptive effect in acetic acid--acetylcholine--and hypertonic saline--induced abdominal constrictions, but not in hot-plate and tail flick tests. P. alliacea did not produce any CNS depressor effect. Thus its antinociceptive action in animals can be responsible by its popular use as an analgesic. |
| Databáze: | OpenAIRE |
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